2016
Methylphenidate Modulates Functional Network Connectivity to Enhance Attention
Rosenberg MD, Zhang S, Hsu WT, Scheinost D, Finn ES, Shen X, Constable RT, Li CS, Chun MM. Methylphenidate Modulates Functional Network Connectivity to Enhance Attention. Journal Of Neuroscience 2016, 36: 9547-9557. PMID: 27629707, PMCID: PMC5039242, DOI: 10.1523/jneurosci.1746-16.2016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSustained attentionWhole-brain connectivity patternsFunctional brain networksHyperactivity disorderBrain networksConnectivity patternsConnectome-based predictive modeling approachWhole-brain functional connectivity patternsWhole-brain functional connectivity networksSustained attention taskStop-signal taskDose of methylphenidateFunctional network connectivityCausal roleFunctional connectivity patternsHealthy adultsAttention taskCognitive abilitiesPromising neuromarkerNetwork strengthBehavioral predictionsADHD treatmentConnectivity signaturesFunctional connectivity networks
2014
The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults
Farr OM, Zhang S, Hu S, Matuskey D, Abdelghany O, Malison RT, Li CS. The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. The International Journal Of Neuropsychopharmacology 2014, 17: 1177-1191. PMID: 24825078, PMCID: PMC4506752, DOI: 10.1017/s1461145714000674.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCorpus StriatumFemaleFunctional NeuroimagingHealthy VolunteersHumansMagnetic Resonance ImagingMaleMethylphenidateNeural PathwaysRestThalamusYoung AdultConceptsEffects of methylphenidateResting-state connectivityFunctional connectivityResting-state functional connectivityFrontal executive areasRegional brain activationAmygdala/hippocampusPrefrontal cortical connectivityDorsal striatumHealthy adultsCognitive performanceBrain activationExecutive areasGlobal functional connectivityCatecholaminergic signalingMotor cortexBrain regionsBrain functionPrimary motor cortexCortical connectivityCerebral connectivityMemory circuitsCatecholaminergic dysfunctionMethylphenidatePsychiatric disordersThe Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCentral Nervous System StimulantsFemaleHealthy VolunteersHumansMagnetic Resonance ImagingMaleMethylphenidateReaction TimeYoung AdultConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependence
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingCentral Nervous System StimulantsFrontal LobeHumansInhibition, PsychologicalLimbic SystemMotivationNeural PathwaysStress, PsychologicalSubstance-Related DisordersConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction