2023
Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men
Li G, Zhong D, Li B, Chen Y, Yang L, Li C. Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men. The International Journal Of Neuropsychopharmacology 2023, 26: 879-889. PMID: 37924270, PMCID: PMC10726414, DOI: 10.1093/ijnp/pyad062.Peer-Reviewed Original ResearchThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2022
Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2020
Neural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits
Li G, Zhang S, Le TM, Tang X, Li CR. Neural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits. NeuroImage 2020, 221: 117171. PMID: 32682098, PMCID: PMC7789231, DOI: 10.1016/j.neuroimage.2020.117171.Peer-Reviewed Original ResearchConceptsNegative facial emotionsFacial emotionsMiddle frontal cortexShape targetRetrosplenial cortexEmotion processingIndividual differencesProlonged RTHigher activationRight middle frontal cortexLeft retrosplenial cortexBilateral middle frontal cortexFrontal cortexSex-specific behavioralShape identificationHuman Connectome ProjectRegional brain responsesEmotion measuresAffective traitsNeural processesBrain responsesFear traitsNeural responsesEmotional disordersIndividuals' anger
2019
Striatal functional connectivity in chronic ketamine users: a pilot study
Hung CC, Zhang S, Chen CM, Duann JR, Lin CP, Lee TS, Li CR. Striatal functional connectivity in chronic ketamine users: a pilot study. The American Journal Of Drug And Alcohol Abuse 2019, 46: 31-43. PMID: 31264888, PMCID: PMC8627683, DOI: 10.1080/00952990.2019.1624764.Peer-Reviewed Original ResearchConceptsDuration of useChronic ketamine usersKetamine usersKetamine useKetamine misuseOrbitofrontal cortexFunctional connectivityStriatal functional connectivityState functional connectivityLeft orbitofrontal cortexBIS-11 scoresDorsal anterior cingulate cortexVoxel-wise connectivityAnterior cingulate cortexMagnetic resonance imagingOFC connectivityHealthy controlsBilateral cerebellumStriatal connectivityCingulate cortexResonance imagingControl dysfunctionVentral striatumZ-scorePilot studyPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2017
Depression in chronic ketamine users: Sex differences and neural bases
Li CR, Zhang S, Hung CC, Chen CM, Duann JR, Lin CP, Lee TS. Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Research Neuroimaging 2017, 269: 1-8. PMID: 28892733, PMCID: PMC5634929, DOI: 10.1016/j.pscychresns.2017.09.001.Peer-Reviewed Original ResearchConceptsHealthy controlsSgACC connectivityChronic ketamine usersKetamine usersOrbitofrontal cortexEpidemiological Studies Depression ScaleSubgenual anterior cingulate cortexSex differencesPathogenesis of depressionCES-D scoresState functional connectivityBilateral superior temporal gyrusChronic ketamine useAnterior cingulate cortexSuperior temporal gyrusNeural basisDepression ScaleDorsomedial prefrontal cortexDepression scoresDepression severityKetamine useCingulate cortexTemporal gyrusFunctional connectivityPrefrontal cortex
2016
A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
Manza P, Hu S, Chao HH, Zhang S, Leung HC, Li CS. A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action. NeuroImage 2016, 134: 466-474. PMID: 27126003, PMCID: PMC4912860, DOI: 10.1016/j.neuroimage.2016.04.055.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal reaction timeAnterior cingulate cortexSignal reaction timeCingulate cortexResponse inhibitionMotor inhibitionPre-supplementary motor areaRegional activationPre-SMA functionRegional brain activationMotor response inhibitionMotor areaStop trialsSalience processingBrain activationSalience detectionSuccess trialsSignal taskTrialsInhibitionSuccessful inhibitionInfrequent stimuliCortexActivationThe effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
Manza P, Hu S, Ide JS, Farr OM, Zhang S, Leung HC, Li CR. The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task. Journal Of Psychopharmacology 2016, 30: 283-293. PMID: 26755547, PMCID: PMC4837899, DOI: 10.1177/0269881115625102.Peer-Reviewed Original ResearchConceptsUnsigned prediction errorsStop-signal taskConflict anticipationVentromedial prefrontal cortexEffects of methylphenidateDorsal anterior cingulateInferior parietal lobulePresupplementary motor areaCognitive controlHealthy young adultsNeural processesUpcoming conflictTask performanceNeural mechanismsBilateral caudate headParietal lobulePrediction errorPrefrontal cortexAnterior cingulateAdaptive behaviorParahippocampal gyrusMethylphenidateMotor areaAnticipation activityYoung adults
2015
Causal Interactions Within a Frontal-Cingulate-Parietal Network During Cognitive Control: Convergent Evidence from a Multisite–Multitask Investigation
Cai W, Chen T, Ryali S, Kochalka J, Li CS, Menon V. Causal Interactions Within a Frontal-Cingulate-Parietal Network During Cognitive Control: Convergent Evidence from a Multisite–Multitask Investigation. Cerebral Cortex 2015, 26: 2140-2153. PMID: 25778346, PMCID: PMC4830290, DOI: 10.1093/cercor/bhv046.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexCognitive controlAnterior insulaParietal networkCausal interactionsCognitive control resourcesCognitive control abilitiesCognitive control processesCognitive control modelCognitive control taskGoal-directed behaviorAnterior cingulate cortexSignificant causal influenceBrain mechanismsIndividual differencesCausal outflowCingulate cortexFMRI dataControl taskCausal hubCausal influenceControl abilityControl processControl resourcesTaskPerigenual anterior cingulate event-related potential precedes stop signal errors
Chang A, Chen CC, Li HH, Li CS. Perigenual anterior cingulate event-related potential precedes stop signal errors. NeuroImage 2015, 111: 179-185. PMID: 25700955, PMCID: PMC4511155, DOI: 10.1016/j.neuroimage.2015.02.017.Peer-Reviewed Original Research
2013
Bayesian Prediction and Evaluation in the Anterior Cingulate Cortex
Ide JS, Shenoy P, Yu AJ, Li CS. Bayesian Prediction and Evaluation in the Anterior Cingulate Cortex. Journal Of Neuroscience 2013, 33: 2039-2047. PMID: 23365241, PMCID: PMC3711643, DOI: 10.1523/jneurosci.2201-12.2013.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal taskAnterior cingulate cortexBayesian ideal observer modelCingulate cortexCognitive control functionsFunctional magnetic resonance imagingNeural recording studiesIdeal observer modelPrediction errorMonitoring of conflictStimulus expectationError likelihoodError anticipationResponse errorsObserver modelRecording studiesProbabilistic expectationsResponse outcomesTaskCortexHemodynamic responseMagnetic resonance imagingConflictExpectations
2010
Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study
Rando K, Hong KI, Bhagwagar Z, Li CS, Bergquist K, Guarnaccia J, Sinha R. Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study. American Journal Of Psychiatry 2010, 168: 183-192. PMID: 21078704, PMCID: PMC3668974, DOI: 10.1176/appi.ajp.2010.10020233.Peer-Reviewed Original ResearchConceptsGray matter volume deficitsGray matter volumeAlcohol-dependent patientsMatter volumeVolume deficitsAlcohol relapseRelapse riskComparison subjectsBrain regionsCortical gray matter volumeAlcohol useRegional brain volume differencesSmaller gray matter volumePoor clinical outcomeBrain volume deficitsFrontal gray matter volumeGray matter atrophyAbstinent alcohol-dependent patientsAlcoholism treatment outcomeHigh-resolution structural MRIProspective study designHealthy comparison subjectsVoxel-based morphometryAlcohol-dependent groupMonths of abstinence
2005
Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals
Li CS, Milivojevic V, Constable RT, Sinha R. Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals. Psychiatry Research 2005, 140: 271-280. PMID: 16290108, DOI: 10.1016/j.pscychresns.2005.09.002.Peer-Reviewed Original ResearchConceptsPerigenual anterior cingulateAbstinent cocaine-dependent subjectsCocaine-dependent subjectsCannabis abuseCannabis abusersCocaine-dependent individualsAnterior cingulateEmotional stressBOLD signalUrine drug screeningSame statistical thresholdDrug use historyFrontal cortical areasHeavy cannabis useLevel-dependent contrastPrevious neuroimaging studiesFunctional magnetic resonanceFrontal cortexCortical areasAlcohol consumptionCortical activationEmotional stress taskUse of marijuanaBrain regionsDecreased activationSex differences in brain activation during stress imagery in abstinent cocaine users: A functional magnetic resonance imaging study
Li CS, Kosten TR, Sinha R. Sex differences in brain activation during stress imagery in abstinent cocaine users: A functional magnetic resonance imaging study. Biological Psychiatry 2005, 57: 487-494. PMID: 15737663, DOI: 10.1016/j.biopsych.2004.11.048.Peer-Reviewed Original ResearchConceptsAbstinent cocaine usersStress imageryBrain activationAnterior cingulateCingulate cortexFunctional magnetic resonance imaging sessionFunctional magnetic resonance imaging studyMagnetic resonance imaging sessionScript-guided imageryInferior frontal cortexStress-induced cocaineCocaine usersPosterior cingulate cortexRight posterior cingulate cortexSex differencesMagnetic resonance imaging studyImagery vividnessResonance imaging studyFrontolimbic activityImagery periodMore activationDrug seekingFunctional neuroimagingCoping strategiesCocaine-dependent subjects