2010
Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study
Rando K, Hong KI, Bhagwagar Z, Li CS, Bergquist K, Guarnaccia J, Sinha R. Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study. American Journal Of Psychiatry 2010, 168: 183-192. PMID: 21078704, PMCID: PMC3668974, DOI: 10.1176/appi.ajp.2010.10020233.Peer-Reviewed Original ResearchConceptsGray matter volume deficitsGray matter volumeAlcohol-dependent patientsMatter volumeVolume deficitsAlcohol relapseRelapse riskComparison subjectsBrain regionsCortical gray matter volumeAlcohol useRegional brain volume differencesSmaller gray matter volumePoor clinical outcomeBrain volume deficitsFrontal gray matter volumeGray matter atrophyAbstinent alcohol-dependent patientsAlcoholism treatment outcomeHigh-resolution structural MRIProspective study designHealthy comparison subjectsVoxel-based morphometryAlcohol-dependent groupMonths of abstinenceIncreased error-related thalamic activity during early compared to late cocaine abstinence
Li CS, Luo X, Sinha R, Rounsaville BJ, Carroll KM, Malison RT, Ding YS, Zhang S, Ide JS. Increased error-related thalamic activity during early compared to late cocaine abstinence. Drug And Alcohol Dependence 2010, 109: 181-189. PMID: 20163923, PMCID: PMC2875333, DOI: 10.1016/j.drugalcdep.2010.01.008.Peer-Reviewed Original Research
2007
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA R, LI C. Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications. Drug And Alcohol Review 2007, 26: 25-31. PMID: 17364833, DOI: 10.1080/09595230601036960.Peer-Reviewed Original ResearchConceptsRelapse outcomesDrug-related cuesPosterior insula regionsCue-induced cravingDrug cue exposureCue-induced drugBrain imaging studiesDrug cuesNeural correlatesCorticostriatal-limbic circuitryCue exposureInsula regionsBrain correlatesRelapse propensityMedial prefrontalBehavioral treatmentAddictive disordersAlcohol cravingPosterior cingulateNeural activityBrain regionsArousal responseLimbic circuitryNeural circuitsCraving