2022
Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia
Wang L, Zeng W, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Luo X, Tan S, Wang Z, Li C, Tian B, Tian L, Ma C, Li Y, Tan Y. Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia. Asian Journal Of Psychiatry 2022, 80: 103385. PMID: 36542893, DOI: 10.1016/j.ajp.2022.103385.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesElectroencephalographyEvoked Potentials, AuditoryHumansSchizophreniaSensory GatingSurveys and QuestionnairesConceptsSensory gating deficitsFirst-episode schizophreniaGating deficitsS1-S2 differenceHealth controlsChildhood Trauma QuestionnaireChildhood trauma experiencesChildhood traumaS2/S1 ratioOnset of schizophreniaTrauma experiencesP50 sensory gatingSevere childhood traumaEmotional neglectSchizophrenia onsetS1 ratioSensory gatingAuditory conditioningEarly interventionCTQ totalSchizophreniaTraumaTrauma QuestionnaireStimulus paradigmPartial correlation analysis
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchMeSH KeywordsAdult Survivors of Child AbuseBipolar DisorderChildChild AbuseDefense MechanismsDiagnostic and Statistical Manual of Mental DisordersHumansSurveys and QuestionnairesConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma Questionnaire
2019
Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectancies
2017
Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study
Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesGray matter volumeAlcohol expectanciesAlcohol Use Disorders Identification TestSocial drinkersNon-dependent social drinkersProblem drinkingRole of impulsivityBrain imaging studiesRight posterior insulaSex differencesStructural brain imagingStructural brain imaging studiesNeural basisDisorders Identification TestBarratt impulsivityPsychological factorsImpulsivityMediation analysisPosterior insulaDependent individualsRisk factorsAlcohol misuseLinear modelingGeneral linear modeling
2014
Clinical characteristics and diagnostic confirmation of Internet addiction in secondary school students in Wuhan, China
Tang J, Zhang Y, Li Y, Liu L, Liu X, Zeng H, Xiang D, Li C, Lee T. Clinical characteristics and diagnostic confirmation of Internet addiction in secondary school students in Wuhan, China. Psychiatry And Clinical Neurosciences 2014, 68: 471-478. PMID: 24920380, DOI: 10.1111/pcn.12153.Peer-Reviewed Original Research
2013
Improvement of quality of life in methadone treatment patients in northern Taiwan: a follow-up study
Chou YC, Shih SF, Tsai WD, Li CS, Xu K, Lee TS. Improvement of quality of life in methadone treatment patients in northern Taiwan: a follow-up study. BMC Psychiatry 2013, 13: 190. PMID: 23865898, PMCID: PMC3722024, DOI: 10.1186/1471-244x-13-190.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollow-Up StudiesHeroin DependenceHumansMaleMethadoneMiddle AgedNarcoticsOpiate Substitution TreatmentProspective StudiesQuality of LifeSurveys and QuestionnairesTaiwanConceptsMethadone maintenance treatmentLong-term qualityMaintenance treatmentMethadone treatment patientsHeroin-dependent individualsWHOQOL-BREF questionnaireQuality of lifeSocial relationship domainLong-term improvementClinical characteristicsTreatment patientsBackgroundThis studyHeroin usersSignificant improvementWHOQOL-BREFImprovement of qualityMethodsThe sampleConsent formNorthern TaiwanRelationship domainPatientsBaselineMonthsTreatmentEnvironmental domains
2012
Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS. Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis. BMC Cancer 2012, 12: 371. PMID: 22925152, PMCID: PMC3502584, DOI: 10.1186/1471-2407-12-371.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrogen AntagonistsAnilidesAntineoplastic Agents, HormonalBrainCognitionCohort StudiesGoserelinHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedNeuropsychological TestsNitrilesProspective StudiesProstatic NeoplasmsPsychomotor PerformanceQuality of LifeSurveys and QuestionnairesTosyl CompoundsTreatment OutcomeConceptsAndrogen deprivation therapyFunctional magnetic resonance imagingProspective observational cohort analysisObservational cohort analysisN-back taskStop-signal taskCognitive controlProstate cancerBrain activationCohort analysisLow-risk prostate cancerNon-metastatic prostate cancerVeterans Affairs Medical CenterLong-term clinical implicationsBrain connectivityProstate cancer patientsPrefrontal cortical activationQuality of lifeFunctional brain connectivityMagnetic resonance imagingMedial prefrontal cortexParticular clinical concernDeprivation therapyADT useAndrogen deprivation
2006
Obsessive–compulsiveness and impulsivity in a non-clinical population of adolescent males and females
Li CS, Chen SH. Obsessive–compulsiveness and impulsivity in a non-clinical population of adolescent males and females. Psychiatry Research 2006, 149: 129-138. PMID: 17046069, DOI: 10.1016/j.psychres.2006.05.001.Peer-Reviewed Original ResearchConceptsMaudsley Obsessive-Compulsive InventoryLack of perseveranceBIS-11Impulsive behaviorNon-clinical adolescent populationBarratt Impulsiveness ScaleNon-clinical populationsObsessive-Compulsive InventoryBIS-11 scoresIntrusive thoughtsRepetitive checkingHigh school studentsPsychological dimensionsImpulsiveness ScaleNeurobiological basisImpulsivityOverall internal consistencyAdolescent malesGood overall internal consistencyCertain psychiatric conditionsInternal consistencyAdolescent populationPsychiatric conditionsChinese versionParticipants
2003
Auditory discrimination in female adolescents varying in schizotypal features: Preliminary findings
Li C, Yang Y, Chen M, Chen WJ, Liu J. Auditory discrimination in female adolescents varying in schizotypal features: Preliminary findings. Psychiatry And Clinical Neurosciences 2003, 57: 391-397. PMID: 12839520, DOI: 10.1046/j.1440-1819.2003.01137.x.Peer-Reviewed Original ResearchConceptsSchizotypal Personality QuestionnaireAuditory discriminationPerceptual Aberration ScaleResponse biasSchizotypal featuresSPQ scoresChinese Health QuestionnaireImpaired auditory processingHigher SPQ scoresSignal detection theoryFemale adolescent subjectsPreliminary findingsAuditory perceptionDiscrimination taskAuditory processingImpaired performanceAuditory detectionDetection theoryPersonality QuestionnaireFemale adolescentsAuditory hallucinationsPsychological statusSchizophrenia patientsYoung adultsGroups of subjects