2006
Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
Li CS, Milivojevic V, Kemp K, Hong K, Sinha R. Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug And Alcohol Dependence 2006, 85: 205-212. PMID: 16725282, DOI: 10.1016/j.drugalcdep.2006.04.008.Peer-Reviewed Original ResearchConceptsImpaired response inhibitionStop-signal taskResponse inhibitionCognitive processesCocaine-dependent patientsSignal taskResponse readinessTask-related cognitive processesCritical cognitive mechanismsPerformance monitoringMeasures of impulsivityEducation-matched healthy controlsSignal reaction timeAbstinent cocaine-dependent patientsHorse-race modelCognitive mechanismsPSS effectCocaine subjectsRace modelHealthy controlsSubstance abusersAbstinent patientsSSRTStop signalCocaine dependence
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge