2023
Role of the immune-kynurenine pathway in treatment-resistant schizophrenia
Chen W, Tian Y, Gou M, Wang L, Tong J, Zhou Y, Feng W, Li Y, Chen S, Liu Y, Wang Z, Pan S, Zhang P, Huang J, Yang X, Li C, Tian L, Hong L, Tan Y. Role of the immune-kynurenine pathway in treatment-resistant schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 130: 110926. PMID: 38147973, DOI: 10.1016/j.pnpbp.2023.110926.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemTreatment-resistant schizophreniaQUIN/KYNA ratioNon-TRS patientsHealthy controlsKynurenine pathwayKP metabolismKP activationKynurenic acidQuinolinic acidInflammation-related effectsPeripheral immune responseAnti-inflammatory cytokinesPro-inflammatory cytokinesBinary logistic regression analysisPathophysiology of schizophreniaLogistic regression analysisAge of onsetLower kynurenineKP metabolitesKYNA levelsIllness onsetPlasma levelsRisk factorsNMDA receptorsOvernight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers
Chen Y, Li C. Overnight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers. Journal Of Integrative Neuroscience 2023, 22: 66. PMID: 37258442, DOI: 10.31083/j.jin2203066.Peer-Reviewed Original ResearchConceptsPersonality traitsOvernight abstinenceTridimensional Personality QuestionnaireState functional magnetic resonance imaging scansFunctional magnetic resonance imaging (fMRI) scansPersonality risk factorsIndividual personality traitsMagnetic resonance imaging (MRI) scansState functional connectivityShort-term abstinenceResonance imaging scansRisk of smokingInter-regional connectivityNicotine deprivationHarm avoidanceConnectivity correlatesNeural markersCigarette smokingFunctional connectivityCigarette smokersPersonality QuestionnaireImaging scansRisk factorsDorsal striatumNicotine dependence
2022
Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents
Ottino‐González J, Garavan H, Albaugh M, Cao Z, Cupertino R, Schwab N, Spechler P, Allen N, Artiges E, Banaschewski T, Bokde A, Burke Quinlan E, Brühl R, Orr C, Cousijn J, Desrivières S, Flor H, Foxe J, Fröhner J, Goudriaan A, Gowland P, Grigis A, Heinz A, Hester R, Hutchison K, Li C, London E, Lorenzetti V, Luijten M, Nees F, Martín‐Santos R, Martinot J, Millenet S, Momenan R, Paillère Martinot M, Papadopoulos Orfanos D, Paulus M, Poustka L, Schmaal L, Schumann G, Sinha R, Smolka MN, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst RJ, Veltman DJ, Walter H, Whelan R, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S. Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents. Addiction 2022, 117: 1312-1325. PMID: 34907616, DOI: 10.1111/add.15772.Peer-Reviewed Original ResearchConceptsAlcohol dependenceHeavy drinking adolescentsStructural covariance networksAge 19Non-dependent controlsPre-existing risk factorsAge 14Cohort of adolescentsCross-sectional analysisRisk factorsAlcohol exposureEnhancing Neuroimaging GeneticsCortical thicknessHazardous drinkersEarly markerMeta-AnalysisNetwork segregationCross-sectional sampleIMAGEN studySubstantial exposureAdultsDrinking adolescentsCovariance networksBrain organizationAdolescents
2021
Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults
Dong X, Zhang R, Zhornitsky S, Le TM, Wang W, Li CR, Zhang S. Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults. Journal Of Clinical Medicine 2021, 10: 5015. PMID: 34768534, PMCID: PMC8584624, DOI: 10.3390/jcm10215015.Peer-Reviewed Original ResearchChildhood traumaYoung adultsSex differencesPsychological risk factorsRisk factorsSevere depressionSignificant associationSociodemographic characteristicsTraumaFuture preventionControl participantsDepressionIntervention strategiesStandardized assessmentSeverityAddictionFemalesMalesEmotional neglectAdultsAdolescentsSexual abuseBehavioral addictionsA Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint)
Fucito LM, Ash GI, DeMartini KS, Pittman B, Barnett NP, Li CR, Redeker NS, O'Malley SS. A Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint). JMIR Research Protocols 2021, 10: e26557. PMID: 33635276, PMCID: PMC7954653, DOI: 10.2196/26557.Peer-Reviewed Original ResearchSleep hygiene adviceINTERNATIONAL REGISTERED REPORT IDENTIFIERHeavy-drinking young adultsHygiene adviceSleep interventionsYoung adultsAlcohol diaryAlcohol use disorder riskRisky alcohol consumptionAlcohol use disorderLow-cost interventionAlcohol behavior changeControlled TrialsWeb-based sessionsBrief adviceHealth coachesRisk factorsPoor sleepRecent heavy drinkingSleep characteristicsUse disordersAlcohol consumptionAlcohol-related consequencesPriority populationsSecondary aim
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma Questionnaire
2017
Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study
Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesGray matter volumeAlcohol expectanciesAlcohol Use Disorders Identification TestSocial drinkersNon-dependent social drinkersProblem drinkingRole of impulsivityBrain imaging studiesRight posterior insulaSex differencesStructural brain imagingStructural brain imaging studiesNeural basisDisorders Identification TestBarratt impulsivityPsychological factorsImpulsivityMediation analysisPosterior insulaDependent individualsRisk factorsAlcohol misuseLinear modelingGeneral linear modeling