2020
Functional disconnection between subsystems of the default mode network in schizophrenia
Fan F, Tan S, Huang J, Chen S, Fan H, Wang Z, Li CR, Tan Y. Functional disconnection between subsystems of the default mode network in schizophrenia. Psychological Medicine 2020, 52: 2270-2280. PMID: 33183375, DOI: 10.1017/s003329172000416x.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaDysfunctional default mode networkDefault mode networkRecurrent schizophreniaIllness durationHealthy controlsSchizophrenia patientsConnectivity strengthResting-state functional connectivity analysisReduced connectivity strengthMode networkFunctional connectivity analysisClinical symptomsPatient groupConnectivity deficitsEarly diagnosisFunctional disconnectionIndependent cohortRES groupMTL dysfunctionPatientsDMN subsystemsFunctional connectivitySchizophreniaMTL subsystemPain and reward circuits antagonistically modulate alcohol expectancy to regulate drinking
Le TM, Zhornitsky S, Zhang S, Li CR. Pain and reward circuits antagonistically modulate alcohol expectancy to regulate drinking. Translational Psychiatry 2020, 10: 220. PMID: 32636394, PMCID: PMC7341762, DOI: 10.1038/s41398-020-00909-z.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPath modelCue exposure taskWhole-brain regressionAlcohol cue exposurePAG connectivityPotential aversive effectsExposure tasksCue exposureAlcohol expectanciesSocial pleasureDrinking severityOrbitofrontal cortexFMRI dataConnectivity strengthPrecentral gyrusOccipital cortexPSP scoresAlcohol useAversive effectsExcessive drinkingNegative associationExpectancyPleasureCortex
2018
Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study
Zhang S, Wang W, Zhornitsky S, Li CR. Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study. Frontiers In Psychiatry 2018, 9: 344. PMID: 30100886, PMCID: PMC6072838, DOI: 10.3389/fpsyt.2018.00344.Peer-Reviewed Original ResearchState functional connectivityMedial hypothalamusHealthy controlsCocaine dependenceDorsolateral prefrontal cortexFunctional connectivityHypothalamic connectivityPrefrontal cortexVentral striatumCocaine misuseConnectivity strengthCocaine Craving QuestionnaireRole of dopamineInferior parietal lobuleLateral hypothalamusTrend-level significanceMesocorticolimbic circuitPreclinical workHypothalamusVentromedial prefrontal cortexCocaine usePast monthParietal lobuleTemporal gyrusHypothalamus functions