2018
Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies
Peterson AC, Li CR. Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies. Frontiers In Aging Neuroscience 2018, 10: 127. PMID: 29765316, PMCID: PMC5938376, DOI: 10.3389/fnagi.2018.00127.Peer-Reviewed Original ResearchNoradrenergic dysfunctionParkinson's diseaseAlzheimer's diseaseDefault mode networkMRI studiesImaging studiesPathogenesis of ADPostmortem anatomical studiesConventional therapeutic strategiesControl network activityStructural MRI studiesMagnetic resonance imagingFunctional MRI studyHuman imaging studiesLC degenerationCerebral cortexNoradrenergic projectionsDopaminergic neurotransmissionNoradrenergic systemTherapeutic strategiesMedication developmentFunctional alterationsCognitive declineCognitive impairmentDysfunction
2016
Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences
Zhang S, Hu S, Fucito LM, Luo X, Mazure CM, Zaborszky L, Li CR. Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences. Nicotine & Tobacco Research 2016, 19: 452-459. PMID: 27613921, PMCID: PMC6074817, DOI: 10.1093/ntr/ntw209.Peer-Reviewed Original ResearchConceptsSupplementary motor areaCigarette smokersCholinergic systemCigarette smokingFemale smokersMotor areaBasal nucleusFunctional connectivityResting-state functional connectivityGender-matched nonsmokersWhole-brain functional connectivityNicotine dependence scoresBilateral anterior insulaNicotinic acetylcholine receptorsPosterior cingulate cortexCurrent smokersMale smokersCerebral cortexCholinergic projectionsMultiple imaging modalitiesBasal forebrainGreater negative connectivitySex-specific differencesSmokersFagerström Test
2015
Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age
Zhang S, Hu S, Chao HH, Li CR. Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age. Cerebral Cortex 2015, 26: 3413-3427. PMID: 26223261, PMCID: PMC4961017, DOI: 10.1093/cercor/bhv172.Peer-Reviewed Original ResearchConceptsVentral tegmental area/substantia nigra pars compactaSubstantia nigra pars compactaLocus coeruleusPars compactaFunctional connectivityResting-state functional connectivityCerebral functional connectivityNumerous animal studiesFronto-parietal cortexRight anterior insulaResting-state fMRI dataEffect of ageCerebral cortexNoradrenergic inputCognitive motor controlAnimal studiesCortex decreasesHealthy adultsCerebellum increasesMidbrain nucleiBilateral amygdalaMidbrain structuresAnterior insulaCognitive manifestationsMotor control
2014
The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood
Manza P, Zhang S, Hu S, Chao HH, Leung HC, Li CS. The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood. NeuroImage 2014, 107: 311-322. PMID: 25514518, PMCID: PMC4300261, DOI: 10.1016/j.neuroimage.2014.12.016.Peer-Reviewed Original ResearchConceptsBasal gangliaNegative connectivityFunctional connectivityState functional magnetic resonanceBasal ganglia nucleiCerebral functional connectivityVentral tegmental area/substantia nigraState functional connectivityAge-related structural changesYears of agePosterior cingulate cortexMedial orbitofrontal cortexDefault mode network regionsFunctional magnetic resonanceCerebellum changesEffect of ageCerebral cortexDopaminergic dysfunctionSubstantia nigraPosterior putamenSomatomotor cortexAdults 18Motor functionVTA/SNMiddle adulthoodResting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age
Li CS, Ide JS, Zhang S, Hu S, Chao HH, Zaborszky L. Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age. NeuroImage 2014, 97: 321-332. PMID: 24736176, PMCID: PMC4065805, DOI: 10.1016/j.neuroimage.2014.04.019.Peer-Reviewed Original ResearchConceptsCerebral functional connectivityFunctional connectivityStronger positive connectivityEffect of ageMotor areaBasal nucleusCognitive declineState functional magnetic resonanceResting-state functional magnetic resonancePositive connectivityPrimary cholinergic inputLoss of neuronsPost-mortem human brainState functional connectivitySupplementary motor areaNumerous animal studiesPre-supplementary motor areaReward-Related BehaviorAnterior cingulate cortexMedial orbitofrontal cortexAge-related cognitive declineAge-related changesFunctional magnetic resonanceVS connectivityCerebral cortex