2023
Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers
Chen Y, Li C. Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers. Addiction Neuroscience 2023, 7: 100089. PMID: 37483686, PMCID: PMC10358306, DOI: 10.1016/j.addicn.2023.100089.Peer-Reviewed Original ResearchCue responsesMonetary incentive delay taskDistinct neural correlatesDistinct neural underpinningsIncentive delay taskNegative emotional statesMid-cingulate cortexMedial cortical regionsDrug cuesNeural underpinningsCue reactivityNeural correlatesSubjective urgeAlcohol expectanciesDelay taskEmotional statesLoss processingSensation seekingVentral striatumAlcohol drinkersAversive componentCortical regionsAversive responsesSubstance misusePotential subtypes
2019
Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers
Wang W, Zhornitsky S, Le TM, Zhang S, Li CR. Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 619-628. PMID: 32061544, PMCID: PMC7286768, DOI: 10.1016/j.bpsc.2019.12.013.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestProblem alcohol useHeart rate variabilityCue exposureAlcohol useAUDIT scoresAutonomic responsesRate variabilityNeutral cue exposureCue exposure paradigmDisorders Identification TestAlcohol cue exposurePrefrontal cortical responsesVentromedial prefrontal cortex activityAlcohol drinkersPrefrontal cortex activityHigher RMSSDCortical responsesParasympathetic responseAlcohol cravingAlcohol misuseVentromedial prefrontal cortexExposure paradigmCortex activityMediation analysisCue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity
2018
Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use
Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.Peer-Reviewed Original ResearchConceptsWhole-brain linear regressionError-related activationSex differencesBilateral dorsal anterior cingulate cortexAlcohol Use Disorders Identification Test (AUDIT) scoresSocial drinkersDorsal anterior cingulate cortexSubstance use disordersAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingSuperior temporal cortexStatistical parametric mappingProblem alcohol useBilateral thalamusAlcohol drinkersAdult social drinkersStop-signal taskMale social drinkersTemporal cortexUse disordersCerebral activationIndependent sample t-testCingulate cortexSubcortical regionsResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2009
Decreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task
Yan P, Li CS. Decreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task. The American Journal Of Drug And Alcohol Abuse 2009, 35: 284-289. PMID: 19579091, PMCID: PMC4511157, DOI: 10.1080/00952990902968569.Peer-Reviewed Original ResearchConceptsStop-signal taskAlcohol drinkersAmygdala activationAlcohol dependenceNon-dependent social drinkersInhibitory controlAlcohol useHabitual alcohol useHeavy alcohol drinkersSignal taskAlcohol-dependent patientsPreliminary fMRI studyAltered brain activationFunctional magnetic resonance imagingMagnetic resonance imagingDependent patientsNeural processesHabitual drinkingHealthy controlsCurrent preliminary studyAlcohol usersResonance imagingStop trialsLight drinkersKey neural processes