2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefits
2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsDietExerciseFemaleHumansLife StyleNutritional StatusTriple Negative Breast NeoplasmsConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBiomarkers, TumorBreast NeoplasmsC-Reactive ProteinFemaleHumansInsulinInsulin-Like Growth Factor ILeptinOvarian NeoplasmsConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomenA qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers
Pichardo M, Irwin M, Sanft T, Ferrucci L, Ginader A, Nguyen T, Esserman D, Cartmel B, Molina Y. A qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers. Supportive Care In Cancer 2023, 31: 111. PMID: 36633678, PMCID: PMC9912693, DOI: 10.1007/s00520-022-07539-9.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBreast NeoplasmsCancer SurvivorsFemaleHealth PersonnelHispanic or LatinoHumansLife StyleConceptsBreast cancer survivorsOncology healthcare providersCancer survivorsLifestyle behaviorsHealthcare providersGeneric messagingEvidence-based knowledgeFemale breast cancer survivorsHealthcare provider counselingHealthy lifestyle guidelinesPatient-level barriersHealthy lifestyle behaviorsLifestyle guidelinesProvider counselingLifestyle factorsOncology careCancer outcomesBreast cancerConsistency of evidenceCurrent evidenceAvailable evidenceSurvivorsCancer diagnosisLevel barriersCancer
2022
Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Irwin M, Ferrucci L. Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors. Journal Of Cancer Survivorship 2022, 17: 535-543. PMID: 36550261, PMCID: PMC10038915, DOI: 10.1007/s11764-022-01325-6.Peer-Reviewed Original ResearchMeSH KeywordsAgedBreast NeoplasmsCancer SurvivorsExerciseFemaleHumansMiddle AgedNeoplasm Recurrence, LocalOvarian NeoplasmsQuality of LifeConceptsOvarian cancer survivorsMin/weekCancer survivorsExercise goalsCancer recurrenceCounseling sessionsSession attendanceExercise adherenceHigher baseline activity levelsWeekly exercise durationTrial of exerciseMean exercise timeVigorous-intensity exerciseBaseline activity levelsQuality of lifeMore counseling sessionsExercise interventionExercise durationWeek exerciseLifestyle StudyExercise timeOvarian cancerNumber of sessionsCounseling intensitySurvivors
2021
Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial
Sanft T, Harrigan M, Cartmel B, Ferrucci LM, Li FY, McGowan C, Zupa M, Nguyen TH, Ligibel J, Neuhouser ML, Hershman DL, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Irwin ML. Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial. Contemporary Clinical Trials 2021, 109: 106508. PMID: 34274495, PMCID: PMC10424280, DOI: 10.1016/j.cct.2021.106508.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsDiet, HealthyExerciseFemaleHumansLife StyleQuality of LifeRandomized Controlled Trials as TopicConceptsChemotherapy completion rateTreatment-related side effectsPhysical activity guidelinesBreast cancerActivity guidelinesCancer survivorsSide effectsWorld Cancer Research FundUsual care control groupCompletion ratesEndocrine therapy adherenceCare control groupHealthy lifestyle interventionRandomized clinical trialsPatient reported outcomesPhysical activity interventionsBreast cancer treatmentAmerican Cancer SocietyBreast cancer prognosisCancer Research FundElectronic medical recordsOncology nutritionTreating oncologistSecondary endpointsChemotherapy session
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2012
The burden of cancer in Connecticut.
Gonsalves L, Cartmel B, Mueller L. The burden of cancer in Connecticut. Connecticut Medicine 2012, 76: 335-51. PMID: 22856019.Peer-Reviewed Original Research