1999
Effects of long-term intake of retinol on selected clinical and laboratory indexes
Cartmel B, Moon T, Levine N. Effects of long-term intake of retinol on selected clinical and laboratory indexes. American Journal Of Clinical Nutrition 1999, 69: 937-943. PMID: 10232634, DOI: 10.1093/ajcn/69.5.937.Peer-Reviewed Original ResearchConceptsRetinol intakeAdverse effectsLaboratory indicesVitamin A/dCoronary artery disease riskCancer chemoprevention trialsLong-term ingestionMinimal adverse effectsLong-term intakeSkin cancer chemoprevention trialAlkaline phosphataseMedian followPlacebo groupChemoprevention trialsClinical symptomsRetinol groupChemopreventive agentsCholesterol concentrationsHealthy populationSkin cancerModerate riskDisease riskIntakeFurther studiesSignificant differences
1997
Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group.
Moon T, Levine N, Cartmel B, Bangert J, Rodney S, Dong Q, Peng Y, Alberts D. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiology Biomarkers & Prevention 1997, 6: 949-56. PMID: 9367069.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaNew squamous-cell carcinomasModerate-risk subjectsSkin cancerHazard ratioNew nonmelanoma skin cancersSquamous cell skin cancerIU of retinolNew skin cancersPlacebo-supplemented subjectsPrimary end pointNonmelanoma skin cancerFree-living subjectsEffect of retinolMedian followOral retinolBasal cell carcinoma skin cancersActinic keratosesRetinol supplementationCell carcinomaDaily supplementationAdverse symptomsEnd pointCancerNew BCC