2024
LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information
Dong Z, Jiang W, Li H, DeWan A, Zhao H. LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information. Briefings In Bioinformatics 2024, 25: bbae335. PMID: 38980374, PMCID: PMC11232466, DOI: 10.1093/bib/bbae335.Peer-Reviewed Original ResearchMeSH KeywordsGene-Environment InteractionGenome-Wide Association StudyHumansLinkage DisequilibriumModels, GeneticMultifactorial InheritancePhenotypePolymorphism, Single NucleotideConceptsHuman complex traitsComplex traitsGene-environment interactionsGene-environmentLinkage disequilibriumPhenotypic variance componentsPhenotypic varianceProportion of phenotypic varianceSummary statisticsEuropean ancestry subjectsUK Biobank dataAssociation summary statisticsComplete linkage disequilibriumControlled type I error ratesLD informationLD matrixVariance componentsBiobank dataType I error rateEuropean ancestrySample size increaseGenetic effectsTraitsE-I pairsSimulation study
2023
Comparison of multiple imputation and other methods for the analysis of imputed genotypes
Auer P, Wang G, Li G, DeWan A, Leal S. Comparison of multiple imputation and other methods for the analysis of imputed genotypes. BMC Genomics 2023, 24: 303. PMID: 37277705, PMCID: PMC10242917, DOI: 10.1186/s12864-023-09415-0.Peer-Reviewed Original ResearchGene FrequencyGenome-Wide Association StudyGenotypeModels, StatisticalPolymorphism, Single NucleotideSaddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies
Johnsen P, Bakke Ø, Bjørnland T, DeWan A, Langaas M. Saddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies. Statistics In Medicine 2023, 42: 2746-2759. PMID: 37094813, DOI: 10.1002/sim.9746.Peer-Reviewed Original ResearchMeSH KeywordsGenome-Wide Association StudyLogistic ModelsPhenotypePolymorphism, Single NucleotideProbabilityDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionType 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAsthmaBronchiolitisBronchiolitis, ViralChildChild, PreschoolGenome-Wide Association StudyHumansHypersensitivity, ImmediateInterleukin-33Respiratory Syncytial Virus, HumanRisk FactorsConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction tests
2020
Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2
Salinas YD, Wang Z, DeWan AT. Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2. American Journal Of Epidemiology 2020, 190: 85-94. PMID: 32700739, PMCID: PMC7784522, DOI: 10.1093/aje/kwaa144.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAsthmaBody Mass IndexFemaleGenome-Wide Association StudyHumansMaleMediation AnalysisMiddle AgedObesityPhenotypeProspective StudiesSex FactorsUnited KingdomConceptsBody mass indexMass indexComorbidity of asthmaWhite British subjectsCross-phenotype associationsAdult asthmaAsthma diagnosisAsthmaConfounder adjustmentAsthma associationsBMI associationsMediation analysisLimited evidenceCandidate gene studiesBMIObesityUK BiobankAssociationDiagnosisTwin studiesAgeFurther characterizationComorbiditiesConfounders
2018
Gene-Gene and Gene-Environment Interactions
DeWan AT. Gene-Gene and Gene-Environment Interactions. Methods In Molecular Biology 2018, 1793: 89-110. PMID: 29876893, DOI: 10.1007/978-1-4939-7868-7_7.BooksConceptsComplex traitsGene-environment interactionsGenome-wide interaction analysisGenetic variantsGenetic architectureDense panelMultiple test correctionGene-GeneTest correctionExplicit testsTraitsHigher-order interactionsRare frequencyInteraction analysisVariantsInteractionSmall effect sizesReplicationInteraction resultsOrder interactionsGWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
2016
Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans
Salinas YD, Wang L, DeWan AT. Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans. BMC Genomic Data 2016, 17: 78. PMID: 27296613, PMCID: PMC4907283, DOI: 10.1186/s12863-016-0387-0.Peer-Reviewed Original ResearchConceptsBody mass indexWomen's Health InitiativeEthnic-specific associationsMass indexSingle nucleotide polymorphismsHealth initiativesAfrican AmericansGreater body mass indexLower body mass indexMulti-Ethnic StudyP-valueAfrican American subjectsAmerican subjectsSuggestive single-nucleotide polymorphismsEuropean-American subjectsGene-based therapiesMultiethnic populationSNP rs12255372Ethnic-specific effectsSignificant associationObesityMESA HispanicsRs12255372BackgroundGenome-wide association studiesConfidence intervals
2012
Whole-exome sequencing of a pedigree segregating asthma
DeWan AT, Egan KB, Hellenbrand K, Sorrentino K, Pizzoferrato N, Walsh KM, Bracken MB. Whole-exome sequencing of a pedigree segregating asthma. BMC Medical Genomics 2012, 13: 95. PMID: 23046476, PMCID: PMC3563469, DOI: 10.1186/1471-2350-13-95.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAsthmaChildExomeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPedigreePhenotypePolymorphism, Single NucleotideYoung AdultConceptsNon-asthmatic childrenWhole-exome sequencingAsthma candidate genesAsthmatic childrenAsthmaAsthma associationsAffected motherExome sequencingUnaffected fatherAsthma-susceptibility variantsPrediction scoreUnaffected offspringCommon risk variantsRisk variantsCandidate genesChildrenNonsynonymous variantsAffected offspring
2010
PDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original Research