2019
Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection
Chen J, Huang Y, Hui Q, Mathur R, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2019, 70: 667-673. PMID: 30893429, PMCID: PMC7319269, DOI: 10.1093/cid/ciz240.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionGlomerular filtration rateKidney functionFiltration rateVirus infectionVeterans Aging Cohort StudyPeripheral blood mononuclear cellsAging Cohort StudyHIV-positive participantsBlood mononuclear cellsMechanisms of HIVCKD riskCohort studyKidney diseaseMononuclear cellsHigh riskHIVPooled populationEGFREpigenetic associationsSignificant CpG sitesGuanine dinucleotide sitesPotential epigenetic mechanismsDNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection
Mathur R, Hui Q, Huang Y, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 2019, 219: 1959-1962. PMID: 30649532, PMCID: PMC6534194, DOI: 10.1093/infdis/jiz023.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionHIV infection statusImmunodeficiency virus infectionVirus infectionVeterans Aging Cohort StudyType 2 diabetes mellitusInfection statusPancreatic β-cell functionAging Cohort StudyΒ-cell functionCohort studyDiabetes mellitusT2DM pathogenesisMale veteransType 2DNA methylation markersSuggestive interactionStatistical significanceMale participantsMellitusT2DMMethylation markersNovel associationsInfectionSuggestive statistical significance
2017
Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study
Freiberg MS, Chang CH, Skanderson M, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Vasan RS, Oursler KA, Gottdiener J, Gottlieb S, Leaf D, Rodriguez-Barradas M, Tracy RP, Gibert CL, Rimland D, Bedimo RJ, Brown ST, Goetz MB, Warner A, Crothers K, Tindle HA, Alcorn C, Bachmann JM, Justice AC, Butt AA. Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study. JAMA Cardiology 2017, 2: 536-546. PMID: 28384660, PMCID: PMC5541383, DOI: 10.1001/jamacardio.2017.0264.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsCase-Control StudiesCD4 Lymphocyte CountCohort StudiesFemaleHeart FailureHIV InfectionsHumansMaleMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsRisk Reduction BehaviorStroke VolumeUnited StatesUnited States Department of Veterans AffairsVeteransViral LoadConceptsRisk of HFrEFHuman immunodeficiency virus (HIV) infectionVeterans Aging Cohort StudyAntiretroviral therapy eraRisk of HFpEFReduced ejection fractionCells/mm3Immunodeficiency virus infectionHeart failureAging Cohort StudyHIV infectionEjection fractionUninfected veteransTherapy eraCohort studyVirus infectionHIV-1 RNA viral loadTime-updated CD4 cell countHIV-specific factorsBaseline cardiovascular diseaseCD4 cell countRNA viral loadCopies/mLRace/ethnicityObservational cohort
2015
Depression and Human Immunodeficiency Virus Infection Are Risk Factors for Incident Heart Failure Among Veterans
White JR, Chang CC, So-Armah KA, Stewart JC, Gupta SK, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Leaf DA, Bedimo RJ, Gottdiener JS, Kop WJ, Gottlieb SS, Budoff MJ, Khambaty T, Tindle HA, Justice AC, Freiberg MS. Depression and Human Immunodeficiency Virus Infection Are Risk Factors for Incident Heart Failure Among Veterans. Circulation 2015, 132: 1630-1638. PMID: 26358261, PMCID: PMC4624488, DOI: 10.1161/circulationaha.114.014443.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingAntidepressive AgentsAnti-HIV AgentsCardiovascular DiseasesComorbidityDepressive Disorder, MajorDiabetes MellitusElectronic Health RecordsEthnicityFemaleFollow-Up StudiesHeart FailureHIV InfectionsHumansHyperlipidemiasIncidenceKidney DiseasesMaleMiddle AgedProspective StudiesRisk FactorsSubstance-Related DisordersUnited StatesVeteransConceptsMajor depressive disorderRisk factorsHuman immunodeficiency virus (HIV) infectionCox proportional hazards modelBaseline antidepressant useIncident HF eventsRisk of HFIncident heart failureImmunodeficiency virus infectionIndependent risk factorCohort Study participantsHeart failure riskProportional hazards modelHF morbidityCommon comorbiditiesIncident HFAntidepressant useHeart failureHIV infectionHIV- participantsPrimary outcomeNinth RevisionHF eventsMedical recordsDepressive disorderThirty-Day Postoperative Mortality Among Individuals With HIV Infection Receiving Antiretroviral Therapy and Procedure-Matched, Uninfected Comparators
King JT, Perkal MF, Rosenthal RA, Gordon AJ, Crystal S, Rodriguez-Barradas MC, Butt AA, Gibert CL, Rimland D, Simberkoff MS, Justice AC. Thirty-Day Postoperative Mortality Among Individuals With HIV Infection Receiving Antiretroviral Therapy and Procedure-Matched, Uninfected Comparators. JAMA Surgery 2015, 150: 343-351. PMID: 25714794, PMCID: PMC5015449, DOI: 10.1001/jamasurg.2014.2257.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionCD4 cell countImmunodeficiency virus infectionAntiretroviral therapyPostoperative mortalityHIV infectionHIV-1 RNAIncidence rate ratiosUninfected patientsVirus infectionCell countUninfected comparatorsSurgical outcomesSurgical proceduresCD4 cell count strataCharlson Comorbidity Index scoreCommon inpatient surgical proceduresHIV-1 RNA levelsThirty-day postoperative mortalityUndetectable HIV-1 RNAVeterans Health Administration healthcare systemElectronic medical record dataCombination antiretroviral therapyComorbidity Index scoreCoronary artery bypass
2013
Management of Human Immunodeficiency Virus Infection in Advanced Age
Greene M, Justice AC, Lampiris HW, Valcour V. Management of Human Immunodeficiency Virus Infection in Advanced Age. JAMA 2013, 309: 1397-1405. PMID: 23549585, PMCID: PMC3684249, DOI: 10.1001/jama.2013.2963.Peer-Reviewed Original ResearchConceptsHIV-positive patientsOlder HIV-positive patientsHuman immunodeficiency virus (HIV) infectionHIV-negative counterpartsComorbid medical illnessesHIV-negative patientsComorbid medical conditionsImmunodeficiency virus infectionHuman immunodeficiency virusLife expectancyMultiple comorbid diseasesLonger life expectancyAntiretroviral regimenOlder HIVAntiretroviral therapyComorbid diseasesConcomitant diseasesPositive patientsMedical illnessImmunodeficiency virusAdvanced ageChronic diseasesChronic illnessConsensus statementVirus infection
2011
Risk of Heart Failure With Human Immunodeficiency Virus in the Absence of Prior Diagnosis of Coronary Heart Disease
Butt AA, Chang CC, Kuller L, Goetz MB, Leaf D, Rimland D, Gibert CL, Oursler KK, Rodriguez-Barradas MC, Lim J, Kazis LE, Gottlieb S, Justice AC, Freiberg MS. Risk of Heart Failure With Human Immunodeficiency Virus in the Absence of Prior Diagnosis of Coronary Heart Disease. JAMA Internal Medicine 2011, 171: 737-743. PMID: 21518940, PMCID: PMC3687533, DOI: 10.1001/archinternmed.2011.151.Peer-Reviewed Original ResearchConceptsIncident HF eventsHeart failureCoronary heart diseaseCopies/mLRisk factorsHIV infectionHF eventsHeart diseaseHigh riskVeterans Aging Cohort Study Virtual CohortHIV-1 RNA levelsRisk of HFCoronary heart disease eventsHuman immunodeficiency virus (HIV) infectionRNA levelsIncident heart failureOngoing viral replicationRetrospective cohort studyHeart disease eventsImmunodeficiency virus infectionHuman immunodeficiency virusVACS-VCVeteran EnrolleesCohort studyPrior diagnosis
2010
Rural Residence Is Associated With Delayed Care Entry and Increased Mortality Among Veterans With Human Immunodeficiency Virus Infection
Ohl M, Tate J, Duggal M, Skanderson M, Scotch M, Kaboli P, Vaughan-Sarrazin M, Justice A. Rural Residence Is Associated With Delayed Care Entry and Increased Mortality Among Veterans With Human Immunodeficiency Virus Infection. Medical Care 2010, 48: 1064-1070. PMID: 20966783, PMCID: PMC3138500, DOI: 10.1097/mlr.0b013e3181ef60c2.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesConfidence IntervalsFemaleHealth Services AccessibilityHIV InfectionsHumansMaleOdds RatioPatient Acceptance of Health CareRetrospective StudiesRisk AssessmentRural Health ServicesRural PopulationSeverity of Illness IndexSurveys and QuestionnairesSurvival AnalysisUnited StatesUrban PopulationVeteransConceptsHuman immunodeficiency virusRural residenceCare entryHazard ratioHIV outcomesHIV severityRural personsVeterans AdministrationCombination antiretroviral therapy useHuman immunodeficiency virus (HIV) infectionRural-Urban Commuting Area codesAdvanced HIV infectionAntiretroviral therapy useRetrospective cohort studyImmunodeficiency virus infectionMortality hazard ratioCommunity-level determinantsRural-urban variationDrug use problemsCART initiationCause mortalityHepatitis CCohort studyHepatitis BHIV infection
2009
Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival
Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Hogg RS, Deeks SG, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Goedert JJ, Benson CA, Collier AC, Van Rompaey SE, Crane HM, McKaig RG, Lau B, Freeman AM, Moore RD. Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival. New England Journal Of Medicine 2009, 360: 1815-1826. PMID: 19339714, PMCID: PMC2854555, DOI: 10.1056/nejmoa0807252.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyRisk of deathAsymptomatic patientsHuman immunodeficiency virus (HIV) infectionCubic millimeterEarly-therapy groupImmunodeficiency virus infectionPrevious antiretroviral therapyCohort of patientsClinical characteristicsHIV infectionRelative riskEarly initiationVirus infectionCD4PatientsMedical careTherapyDeathCalendar yearInfectionRiskCountSurvivalGroup
2008
Workshop on HIV Infection and Aging: What Is Known and Future Research Directions
High K, Effros R, Fletcher C, Gebo K, Halter J, Hazzard W, Horne F, Huebner R, Janoff E, Justice A, Kuritzkes D, Nayfield S, Plaeger S, Schmader K, Ashworth J, Campanelli C, Clayton C, Rada B, Woolard N, High K. Workshop on HIV Infection and Aging: What Is Known and Future Research Directions. Clinical Infectious Diseases 2008, 47: 542-553. PMID: 18627268, PMCID: PMC3130308, DOI: 10.1086/590150.Peer-Reviewed Original ResearchConceptsHIV infectionHuman immunodeficiency virus (HIV) infectionInfectious diseasesImmunodeficiency virus infectionInfectious Diseases SocietyActive antiretroviral treatmentNational InstituteDiseases SocietyAntiretroviral treatmentImmunodeficiency syndromeAdvanced ageChronic diseasesVirus infectionDrug toxicityInfectionSpecialty ProfessorsLife expectancyDiseaseComorbiditiesMedical AssociationHigh-priority topicsTreatmentAssociationAging processPriority topics
2006
Intoxication Before Intercourse and Risky Sexual Behavior in Male Veterans With and Without Human Immunodeficiency Virus Infection
Cook RL, McGinnis KA, Kraemer KL, Gordon AJ, Conigliaro J, Maisto SA, Samet JH, Crystal S, Rimland D, Bryant KJ, Braithwaite RS, Justice AC. Intoxication Before Intercourse and Risky Sexual Behavior in Male Veterans With and Without Human Immunodeficiency Virus Infection. Medical Care 2006, 44: s31-s36. PMID: 16849966, DOI: 10.1097/01.mlr.0000223710.35008.d9.Peer-Reviewed Original ResearchConceptsHIV-positive veteransInconsistent condom useHuman immunodeficiency virus (HIV) infectionHIV-negative veteransImmunodeficiency virus infectionRisky sexual behaviorMale veteransCondom useVirus infectionSexual behaviorSexual partnersVeterans Aging CohortHIV-positive menMeasures of drugMore partnersHIV infectionHIV-positiveOutpatient clinicMeasures of alcoholAging CohortDrug useAlcohol useLast intercourseIntoxicationPast year
2003
Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection
Fultz SL, Justice AC, Butt AA, Rabeneck L, Weissman S, Rodriguez-Barradas M, Team V. Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2003, 36: 1039-1046. PMID: 12684917, DOI: 10.1086/374049.Peer-Reviewed Original ResearchConceptsAlcohol consumptionHepatitis CHuman immunodeficiency virus-positive patientsHepatitis C virus coinfectionHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus-positive patientsC virus coinfectionUnderwent liver biopsyHepatitis C therapyImmunodeficiency virus infectionVirus-positive patientsHepatitis C treatmentTreatment of patientsCohort of veteransVeterans Affairs electronic medical recordsHepatitis C virusCurrent alcohol consumptionHealth care providersElectronic medical recordsC therapyCohort studyLiver biopsyTreatment patternsVirus coinfectionPsychiatric comorbidity