2016
Higher Time-Updated Body Mass Index
Koethe JR, Jenkins CA, Lau B, Shepherd BE, Wester W, Rebeiro PF, Silverberg MJ, Thorne JE, Gill J, Mayor AM, Willig A, Bosch R, Horberg MA, Justice AC, Sterling TR, Moore RD. Higher Time-Updated Body Mass Index. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 73: 197-204. PMID: 27116044, PMCID: PMC5023455, DOI: 10.1097/qai.0000000000001035.Peer-Reviewed Original ResearchConceptsBody mass indexCD4 cell recoveryAntiretroviral therapyCD4 countMass indexNorth American AIDS Cohort CollaborationYears of ARTCell recoveryHigher Body Mass IndexBaseline CD4 countCD4 cell expansionMean CD4 countSuboptimal immune reconstitutionSustained viral suppressionART regimenCohort CollaborationImmune recoveryObese HIVImmune reconstitutionViral suppressionVirologic failureNegative health effectsMultisite cohortPrimary analysisHealth outcomesMortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study
May MT, Vehreschild JJ, Trickey A, Obel N, Reiss P, Bonnet F, Mary-Krause M, Samji H, Cavassini M, Gill MJ, Shepherd LC, Crane HM, Monforte A, Burkholder GA, Johnson MM, Sobrino-Vegas P, Domingo P, Zangerle R, Justice AC, Sterling TR, Miró JM, Sterne JAC, Collaboration F, Boulle A, Stephan C, Miro J, Cavassini M, Chêne G, Costagliola D, Dabis F, Monforte A, del Amo J, Van Sighem A, Fätkenheuer G, Gill J, Guest J, Haerry D, Hogg R, Justice A, Shepherd L, Obel N, Crane H, Smith C, Reiss P, Saag M, Sterling T, Teira R, Williams M, Zangerle R, Sterne J, May M, Ingle S, Trickey A. Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study. Clinical Infectious Diseases 2016, 62: 1571-1577. PMID: 27025828, PMCID: PMC4885653, DOI: 10.1093/cid/ciw183.Peer-Reviewed Original ResearchConceptsStart of ARTMortality rate ratiosCombination antiretroviral therapyAntiretroviral therapyMortality of patientsCD4 countMortality rateLow baseline CD4 countYears of ARTBaseline CD4 countHigher baseline CD4Collaborative Cohort StudyStart of treatmentNorth American cohortStrong inverse associationLong-term survivalShort-term survivalBaseline CD4CD4 groupCohort studyInverse associationPatientsAmerican cohortYears durationMortality
2009
Effect of Baseline CD4 Cell Counts on the Clinical Significance of Short-Term Immunologic Response to Antiretroviral Therapy in Individuals With Virologic Suppression
Moore DM, Harris R, Lima V, Hogg B, May M, Yip B, Justice A, Mocroft A, Reiss P, Lampe F, Chêne G, Costagliola D, Elzi L, Mugavero MJ, Monforte AD, Sabin C, Podzamczer D, Fätkenheuer G, Staszewski S, Gill J, Sterne JA. Effect of Baseline CD4 Cell Counts on the Clinical Significance of Short-Term Immunologic Response to Antiretroviral Therapy in Individuals With Virologic Suppression. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 52: 357-363. PMID: 19668084, PMCID: PMC3032437, DOI: 10.1097/qai.0b013e3181b62933.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyCD4 cell countBaseline CD4 cell countBaseline CD4 countCD4 countImmunologic responseVirologic suppressionCell countAntiretroviral therapyAbsolute CD4Absolute CD4 cell countCD4 cell count strataAdequate immunologic responseART Cohort CollaborationClear therapeutic goalsTreatment-naive individualsCell count strataCART initiationCohort CollaborationCD4 changeHazard ratioViral loadEligible participantsSubsequent prognosisClinical significance