2018
Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis
Grover S, Desir F, Jing Y, Bhatia RK, Trifiletti DM, Swisher-McClure S, Kobie J, Moore RD, Rabkin CS, Silverberg MJ, Salters K, Mathews WC, Gill MJ, Thorne JE, Castilho J, Kitahata MM, Justice A, Horberg MA, Achenbach CJ, Mayor AM, Althoff KN. Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 79: 421-429. PMID: 30211722, PMCID: PMC6203623, DOI: 10.1097/qai.0000000000001842.Peer-Reviewed Original ResearchConceptsLung cancer diagnosisCancer diagnosisLung cancerCancer stageNorth American AIDS Cohort CollaborationAdjusted mortality rate ratioHodgkin lymphoma diagnosisOnly lung cancerRole of HIVRisk of deathMortality rate ratiosCohort CollaborationImmune dysfunctionCervical cancerImmune suppressionCancer outcomesSignificant immunosuppressionCancer survivalPoor survivalLymphoma diagnosisMortality rateProbability of survivalPWHHigh mortalityCancer
2014
Mortality in Patients with HIV-1 Infection Starting Antiretroviral Therapy in South Africa, Europe, or North America: A Collaborative Analysis of Prospective Studies
Boulle A, Schomaker M, May MT, Hogg RS, Shepherd BE, Monge S, Keiser O, Lampe FC, Giddy J, Ndirangu J, Garone D, Fox M, Ingle SM, Reiss P, Dabis F, Costagliola D, Castagna A, Ehren K, Campbell C, Gill MJ, Saag M, Justice AC, Guest J, Crane HM, Egger M, Sterne JA. Mortality in Patients with HIV-1 Infection Starting Antiretroviral Therapy in South Africa, Europe, or North America: A Collaborative Analysis of Prospective Studies. PLOS Medicine 2014, 11: e1001718. PMID: 25203931, PMCID: PMC4159124, DOI: 10.1371/journal.pmed.1001718.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHigh early mortalityEarly mortalityMortality rateAdjusted mortality rate ratioCumulative mortalityDeath registry linkageHIV-1 infectionMortality rate ratiosNorth American cohortSouth African cohortAdvanced diseaseCD4 countRegistry linkageProspective studyVital statusHIV treatmentEuropean cohortPoor ascertainmentHIV-1African cohortAmerican cohortPatientsMortalityCohort