2024
A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients
Du Z, Wang L, Bai Y, Liu Y, Lau E, Galvani A, Krug R, Cowling B, Meyers L. A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients. ELife 2024, 13: e89801. PMID: 38622989, PMCID: PMC11078542, DOI: 10.7554/elife.89801.Peer-Reviewed Original ResearchConceptsViral sheddingHospitalized COVID-19 patientsSARS-CoV-2Retrospective cohort studyRisk of reboundCOVID-19 patientsViral reboundTime of treatmentTreated patientsPreventing severe illnessEarly treatmentCohort studyHospitalized patientsPatientsViral replicationReducing infectiousnessSevere illnessTimely treatmentViral dynamicsHealth record dataTreatmentTransmission riskTransmission of SARS-CoV-2EfficacySymptoms
2015
Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts
Bellan SE, Dushoff J, Galvani AP, Meyers LA. Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts. PLOS Medicine 2015, 12: e1001801. PMID: 25781323, PMCID: PMC4363602, DOI: 10.1371/journal.pmed.1001801.Peer-Reviewed Original ResearchConceptsElevated viral loadAcute phaseViral load trajectoriesSexual network structureViral loadStudy terminationExclusion criteriaRetrospective cohort study designStudy designAcute phase durationSerodiscordant heterosexual couplesRetrospective cohort dataCohort study designProportion of transmissionCourse of infectionRetrospective cohortAntiretroviral treatmentSerodiscordant couplesChronic phaseSimulated cohortRelative hazardCohort dataCohortWide credibility intervalsAdditional risk