Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.
Savinkina A, Muyindike W, Hahn J, Emenyonu N, Fatch R, Ngabirano C, Adong J, Jacobson K, Linas B. Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 335-342. PMID: 38961548, DOI: 10.5588/ijtld.23.0303.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAntitubercular AgentsChemical and Drug Induced Liver InjuryFemaleHIV InfectionsHumansIsoniazidLatent TuberculosisMaleMarkov ChainsMiddle AgedTuberculin TestTuberculosisUgandaYoung AdultConceptsIsoniazid preventive therapyTB preventive therapyTuberculin skin testPreventive therapyReport alcohol useAlcohol useHIV-positive patientsTB disease incidenceLiver enzyme monitoringLatent TB infectionTB burden settingsSkin testTB infectionBurden settingsConsuming alcoholTB diseaseTB riskWHO guidanceTherapyEnzyme monitoringPLWHIsoniazidEvaluate hepatotoxicityHepatotoxicity concernsAST/ALT