2023
An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model
Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsDisease severityViral outbreaksFuture viral outbreaksLength of hospitalizationIntensive care unitWorse disease prognosisLife-threatening illnessEffective medical interventionsCOVID-19Clinical decision treeGlucuronic acid metabolitesNew potential biomarkersHospitalization lengthCare unitComorbidity dataSerotonin levelsDisease progressionHealthy controlsPatient outcomesDisease prognosisPatient transferPatientsHealthcare resourcesPotential biomarkersZika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings
Zhu K, Hill C, Muirhead A, Basu M, Brown J, Brinton M, Hayat M, Venegas-Vargas C, Reis M, Casanovas-Massana A, Meschke J, Ko A, Costa F, Stauber C. Zika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings. Water Research 2023, 241: 120116. PMID: 37270953, PMCID: PMC10330535, DOI: 10.1016/j.watres.2023.120116.Peer-Reviewed Original ResearchConceptsZIKV RNAZIKV outbreakZika virus surveillanceNucleic acid testingZika virus epidemicResource-constrained settingsWidespread diagnostic testingPublic health surveillanceReverse transcription droplet digital PCRTranscription droplet digital PCRAcid testingRNA persistenceDiagnostic testingHealth surveillanceDroplet digital PCRVirus epidemicVirus surveillanceIndividual testingSuch casesDigital PCRSurveillanceOutbreakRNAZIKVRecovery
2020
Transmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC
Anjos RO, Mugabe VA, Moreira PSS, Carvalho CX, Portilho MM, Khouri R, Sacramento GA, Nery NRR, Reis MG, Kitron UD, Ko AI, Costa F, Ribeiro GS. Transmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 1364-1373. PMID: 32568045, PMCID: PMC7323528, DOI: 10.3201/eid2607.190846.Peer-Reviewed Original ResearchConceptsEpisodes of feverChikungunya outbreakInfectious Diseases journal - CDCSymptomatic infection ratePresumptive clinical diagnosisSufficient herd immunityCommunity-based studyFurther longitudinal studiesCHIKV seroprevalenceSeropositive personsVirus seroprevalenceClinical dataHerd immunityChikungunya virusInfection rateClinical diagnosisSerum samplesDisease pointUnpaved streetsArthralgiaLongitudinal studyFeverSeroprevalenceEpisodesOutbreak
2019
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science 2019, 363: 607-610. PMID: 30733412, PMCID: PMC8221194, DOI: 10.1126/science.aav6618.Peer-Reviewed Original ResearchConceptsZika virusZIKV NS1 antigenAttack rateZika virus emergenceHigh antibody titersDengue-endemic regionsZIKV immunityClinical outcomesDengue immunityZIKV infectionAntibody titersNS1 antigenRisk factorsEndemic regionsDengue virusImmunityVirusRiskVirus emergenceFuture transmissionCohortSymptomsInfectionAntigenTiters
2002
Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic.
Sarkar U, Nascimento S, Barbosa R, Martins R, Nuevo H, Kalofonos I, Kalafanos I, Grunstein I, Flannery B, Dias J, Riley L, Reis M, Ko A. Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic. American Journal Of Tropical Medicine And Hygiene 2002, 66: 605-10. PMID: 12201599, DOI: 10.4269/ajtmh.2002.66.605.Peer-Reviewed Original ResearchConceptsRisk factorsUrban epidemicPopulation-based case-control studyPopulation-based case-control investigationIndependent risk factorLaboratory-confirmed casesHealthy neighbourhood controlsCase-control investigationCase-control studyCases of leptospirosisSevere leptospirosisWeil's syndromeWorkplace exposuresNeighborhood controlsHigh endemicityLeptospirosisFocused interventionsMore ratsSyndromeRatsEpidemicEnvironmental sourcesComplicationsFactorsMortality
1999
Urban epidemic of severe leptospirosis in Brazil
Ko A, Reis M, Dourado C, Johnson W, Riley L, Group S. Urban epidemic of severe leptospirosis in Brazil. The Lancet 1999, 354: 820-825. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.Peer-Reviewed Original ResearchConceptsDengue feverInfectious disease referral hospitalAggressive supportive careEpidemic of leptospirosisStrong independent predictorPositive blood culturesLarge urban outbreaksIdentification of leptospiresRenal insufficiencyRespiratory insufficiencySevere leptospirosisSupportive careIndependent predictorsReferral hospitalOutpatient clinicSevere anemiaSevere manifestationsActive surveillanceMental statusRisk factorsBlood culturesDiagnostic confusionUrban epidemicMicroagglutination testUrban outbreaks