2023
Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community
Anjos R, Portilho M, Jacob-Nascimento L, Carvalho C, Moreira P, Sacramento G, Nery N, de Oliveira D, Cruz J, Cardoso C, Argibay H, Plante K, Plante J, Weaver S, Kitron U, Reis M, Ko A, Costa F, Ribeiro G. Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community. PLOS Neglected Tropical Diseases 2023, 17: e0011863. PMID: 38150470, PMCID: PMC10775974, DOI: 10.1371/journal.pntd.0011863.Peer-Reviewed Original ResearchZika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings
Zhu K, Hill C, Muirhead A, Basu M, Brown J, Brinton M, Hayat M, Venegas-Vargas C, Reis M, Casanovas-Massana A, Meschke J, Ko A, Costa F, Stauber C. Zika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings. Water Research 2023, 241: 120116. PMID: 37270953, PMCID: PMC10330535, DOI: 10.1016/j.watres.2023.120116.Peer-Reviewed Original ResearchConceptsZIKV RNAZIKV outbreakZika virus surveillanceNucleic acid testingZika virus epidemicResource-constrained settingsWidespread diagnostic testingPublic health surveillanceReverse transcription droplet digital PCRTranscription droplet digital PCRAcid testingRNA persistenceDiagnostic testingHealth surveillanceDroplet digital PCRVirus epidemicVirus surveillanceIndividual testingSuch casesDigital PCRSurveillanceOutbreakRNAZIKVRecovery
2022
Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil
Aromolaran A, Araujo K, Ladines-Lim JB, Nery N, do Rosário MS, Rastely VN, Archanjo G, Daltro D, da Silveira Carvalho G, Pimentel K, de Almeida JRM, de Siqueira IC, Ribeiro HC, Oliveira-Filho J, de Oliveira D, Henriques DF, Rodrigues SG, da Costa Vasconcelos P, de Almeida ARP, Sacramento GA, Cruz JS, Sarno M, de Paula Freitas B, Mattos A, Khouri R, Reis MG, Ko AI, Costa F. Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil. International Journal Of Infectious Diseases 2022, 120: 201-204. PMID: 35470025, PMCID: PMC9119857, DOI: 10.1016/j.ijid.2022.04.030.Peer-Reviewed Original ResearchConceptsZIKV exposurePregnant womenSocioeconomic statusRelative disease burdenCongenital Zika syndromeZika virus epidemicLow socioeconomic statusZika syndromeClinical presentationDisease burdenSimilar prevalenceSerologic dataDifferent socioeconomic statusS HospitalHospitalLarge hospitalsMicrocephalyStudy centersVirus epidemicWomenPositive associationInfantsUnequal burdenHigh rateExposure rateEVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil
Collins MH, Potter GE, Hitchings MDT, Butler E, Wiles M, Kennedy JK, Pinto SB, Teixeira ABM, Casanovas-Massana A, Rouphael NG, Deye GA, Simmons CP, Moreira LA, Nogueira ML, Cummings DAT, Ko AI, Teixeira MM, Edupuganti S. EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil. Trials 2022, 23: 185. PMID: 35236394, PMCID: PMC8889395, DOI: 10.1186/s13063-022-05997-4.Peer-Reviewed Original ResearchConceptsArboviral infectionsMajor global health problemHigh-quality evidenceCluster-randomized trialGlobal health problemNational InstituteEfficacy of WolbachiaWorld Mosquito ProgramArbovirus transmissionOngoing trialsLicensed antiviralsAedes aegypti mosquitoesEffective vaccineTrial designMosquito ProgramSerologic surveillanceHealth problemsHuman infectionsAedes aegyptiInfectionEpidemiologic outcomesVector control activitiesTrialsAegypti mosquitoesAedes mosquitoes
2021
Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly
Ticona J, Nery N, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, Matos A, de Paula Freitas B, Borja A, Wunder EA, Ballalai V, Vieira C, Cruz JS, de Oliveira D, Araujo DB, Oliveira DB, Maeda D, Mendes EA, Soares C, Durigon EL, de Souza Ferreira LC, Belfort R, Almeida A, Oliveira-Filho J, Reis MG, Ko AI, Costa F. Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly. PLOS ONE 2021, 16: e0256444. PMID: 34525107, PMCID: PMC8443077, DOI: 10.1371/journal.pone.0256444.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeHammersmith Infant Neurological ExaminationHINE scoresZika syndromeHead circumferenceBayley-IIILong-term outcomesGreater head circumferenceSevere developmental delayYears of ageSevere neurodevelopmental delayToddler neurodevelopmentNeurological evaluationMedian ageNeurodevelopmental outcomesNeurological examinationMultivariable analysisNeurodevelopmental assessmentOutpatient clinicNeurodevelopmental evaluationNeurodevelopmental delayBayley ScalesNeurodevelopmental profileSevere microcephalyMild delayDevelopmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohortRisk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents
Ticona J, Baig H, Nery N, Doss-Gollin S, Sacramento GA, Adhikarla H, Muenker MC, Wunder EA, Nascimento EJM, Marques ETA, Reis MG, Ko AI, Costa F. Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents. The Journal Of Infectious Diseases 2021, 224: 860-864. PMID: 33395487, PMCID: PMC8522079, DOI: 10.1093/infdis/jiab001.Peer-Reviewed Original Research
2019
Zika Virus Infection — After the Pandemic
Musso D, Ko AI, Baud D. Zika Virus Infection — After the Pandemic. New England Journal Of Medicine 2019, 381: 1444-1457. PMID: 31597021, DOI: 10.1056/nejmra1808246.Peer-Reviewed Original ResearchRisk of Zika microcephaly correlates with features of maternal antibodies
Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M, Rajagopal L, Waldorf K, Dudley DM, Simmons HA, Mejia A, O’Connor D, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC. Risk of Zika microcephaly correlates with features of maternal antibodies. Journal Of Experimental Medicine 2019, 216: 2302-2315. PMID: 31413072, PMCID: PMC6781003, DOI: 10.1084/jem.20191061.Peer-Reviewed Original ResearchConceptsMaternal antibodiesFetal brain damageSerum antibody responseZika virus infectionInfected pregnanciesMicrocephalic infantsAntibody responsePregnant macaquesRisk factorsBrain damageVirus infectionCongenital abnormalitiesLow titersBrazilian womenMicrocephalyTitersPregnancyZIKVAntibodiesBirthRiskInfantsInfectionAbnormalitiesFlavivirusesImpact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science 2019, 363: 607-610. PMID: 30733412, PMCID: PMC8221194, DOI: 10.1126/science.aav6618.Peer-Reviewed Original ResearchConceptsZika virusZIKV NS1 antigenAttack rateZika virus emergenceHigh antibody titersDengue-endemic regionsZIKV immunityClinical outcomesDengue immunityZIKV infectionAntibody titersNS1 antigenRisk factorsEndemic regionsDengue virusImmunityVirusRiskVirus emergenceFuture transmissionCohortSymptomsInfectionAntigenTiters
2017
Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil
Nogueira ML, Júnior N, Estofolete CF, Terzian A, Guimarães GF, Zini N, da Silva R, Silva G, Franco L, Rahal P, Bittar C, Carneiro B, Vasconcelos PFC, Henriques D, Barbosa DMU, Rombola P, de Grande L, Reis A, Palomares SA, Catelan M, Cruz LEAA, Necchi SH, Mendonça RCV, dos Santos I, Caron S, Costa F, Bozza FA, de Souza A, de Mattos C, de Mattos LC, Vasilakis N, Oliani AH, Oliani D, Ko A. Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil. Clinical Microbiology And Infection 2017, 24: 646-652. PMID: 29133154, DOI: 10.1016/j.cmi.2017.11.004.Peer-Reviewed Original ResearchConceptsAdverse outcomesZIKV infectionPregnant womenZika virusNewborn outcomesCongenital Zika infectionSame adverse outcomesZika virus exposureAdverse birth outcomesBroad clinical spectrumEmergence of ZIKVCases of microcephalyDengue-endemic areasPublic health authoritiesBirth outcomesClinical outcomesClinical presentationThird trimesterSubependymal cystsClinical spectrumZIKV RNAReverse transcription-PCRVirus exposureZika infectionEpidemiologic data