2023
MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection
Zhu W, Passalia F, Hamond C, Abe C, Ko A, Barbosa A, Wunder E. MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection. PLOS Pathogens 2023, 19: e1011313. PMID: 37486929, PMCID: PMC10399853, DOI: 10.1371/journal.ppat.1011313.Peer-Reviewed Original ResearchConceptsOuter membrane proteinsBacterial outer membrane proteinsC-terminal regionSurface-exposed regionsLeptospiral pathogenesisMDCK cell monolayersMembrane proteinsPathogenic LeptospiraImportant virulence factorMutant strainRecombinant proteinsPathogen's abilityVirulence mechanismsLysine residuesKoch's molecular postulatesBinding proteinPlasminogen receptorPathogen disseminationPathogenic spirochetesVirulence factorsProteinBacterial pathogensEssential roleMutantsHost tissues
2003
Monoclonal antibodies against an outer membrane protein from pathogenic Leptospira
Lüdtke C, Coutinho M, Jouglard S, Moreira C, Fernandes C, Brod C, Haake D, Ko A, Dellagostin O, Aleixo J. Monoclonal antibodies against an outer membrane protein from pathogenic Leptospira. Brazilian Journal Of Microbiology 2003, 34: 1-4. DOI: 10.1590/s1517-83822003000500001.Peer-Reviewed Original ResearchBALB/c miceMonoclonal antibodiesPathogenic LeptospiraSP2/OWhole-cell antigen preparationsIndirect ELISANon-pathogenic serovarsIgG2b isotypesC miceSpleen cellsAntigen preparationsMAb specificityDiagnostic testsPathogenic serovarsRecombinant LipL32Non-pathogenic LeptospiraMAbsLeptospiraELISAHybridoma productionAntibodiesLipL32SerovarsOuter membrane proteinsCells