2021
A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus
Wunder EA, Adhikarla H, Hamond C, Bonner K, Liang L, Rodrigues CB, Bisht V, Nally JE, Alt DP, Reis MG, Diggle PJ, Felgner PL, Ko A. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus. ELife 2021, 10: e64166. PMID: 33496263, PMCID: PMC7837694, DOI: 10.7554/elife.64166.Peer-Reviewed Original ResearchConceptsCross-protective immunityPathogenic Leptospira speciesTerms of morbidityLeptospira speciesTransient bacteremiaSingle doseAntibody responseImmune responseApplicable vaccinesVaccine candidatesAnimal modelsEffective preventionAttenuated mutantsZoonotic diseaseLeptospira genusPotential correlatesDisease transmissionDiseaseLeptospirosisImmunityBacteremiaMorbidityImmunizationVaccineRelevant proteins
2019
Tails of Two Cities: Age and Wounding Are Associated With Carriage of Leptospira interrogans by Norway Rats (Rattus norvegicus) in Ecologically Distinct Urban Environments
Minter A, Himsworth C, Byers K, Childs J, Ko A, Costa F. Tails of Two Cities: Age and Wounding Are Associated With Carriage of Leptospira interrogans by Norway Rats (Rattus norvegicus) in Ecologically Distinct Urban Environments. Frontiers In Ecology And Evolution 2019, 7: 14. DOI: 10.3389/fevo.2019.00014.Peer-Reviewed Original ResearchNorway ratsL. interrogansSignificant human morbidityBite woundsGreater oddsGreater prevalenceJuvenile ratsOld ratsRatsHuman morbidityLeptospira interrogansZoonotic diseaseYoung animalsLinear mixed modelsTransmission dynamicsCarriageInterrogansPrevalencePrimary reservoirDistinct urban environmentsRat characteristicsPathogen statusMixed modelsStatusMorbidity
2015
Global Morbidity and Mortality of Leptospirosis: A Systematic Review
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLOS Neglected Tropical Diseases 2015, 9: e0003898. PMID: 26379143, PMCID: PMC4574773, DOI: 10.1371/journal.pntd.0003898.Peer-Reviewed Original ResearchConceptsCase fatality ratioDisease morbidityFatality ratioSystematic reviewMortality of leptospirosisPulmonary hemorrhage syndromeBurden of leptospirosisLife-threatening diseaseDiverse epidemiological settingsResource-poor countriesNumber of deathsHigh morbidityGlobal morbidityGBD regionsGlobal burdenMorbidityZoonotic causesHaemorrhagic feverMortality studyUrban slum dwellersImportant causeDisease statusEpidemiological settingsDisease incidenceWHO regions