2016
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis
Lindow JC, Wunder EA, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N, Relman DA, Kim CC, Reis MG, Ko AI. Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLOS Pathogens 2016, 12: e1005943. PMID: 27812211, PMCID: PMC5094754, DOI: 10.1371/journal.ppat.1005943.Peer-Reviewed Original ResearchConceptsHost immune responseHigh bacterial loadBacterial loadAcute leptospirosisCase fatalityFatal casesDisease progressionImmune responseHigher systemic bacterial loadsValuable new therapeutic approachPro-inflammatory cytokine receptorsAdaptive immune signaturesSystemic bacterial loadsIndependent risk factorTime of hospitalizationDuration of illnessHigh case fatalityPoor clinical outcomeNew therapeutic approachesBlood transcriptional profilingLimited study sizeFatal leptospirosisLethal leptospirosisRANTES levelsSerum cathelicidin
2008
Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums
Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums. PLOS Neglected Tropical Diseases 2008, 2: e228. PMID: 18431445, PMCID: PMC2292260, DOI: 10.1371/journal.pntd.0000228.Peer-Reviewed Original ResearchConceptsLeptospira antibodiesLeptospira infectionRisk factorsIndependent risk factorSocioeconomic statusUrban slumsCommunity-based surveyPopulation-based informationHousehold environmental factorsPoisson regression modelsBlack raceOverall prevalencePrior infectionHealth outcomesHealth problemsUrban leptospirosisInfection riskInfectionSocial gradientUnequal health outcomesEffective preventionLeptospira transmissionTransmission determinantsAntibodiesSystem survey
2002
Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic.
Sarkar U, Nascimento S, Barbosa R, Martins R, Nuevo H, Kalofonos I, Kalafanos I, Grunstein I, Flannery B, Dias J, Riley L, Reis M, Ko A. Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic. American Journal Of Tropical Medicine And Hygiene 2002, 66: 605-10. PMID: 12201599, DOI: 10.4269/ajtmh.2002.66.605.Peer-Reviewed Original ResearchConceptsRisk factorsUrban epidemicPopulation-based case-control studyPopulation-based case-control investigationIndependent risk factorLaboratory-confirmed casesHealthy neighbourhood controlsCase-control investigationCase-control studyCases of leptospirosisSevere leptospirosisWeil's syndromeWorkplace exposuresNeighborhood controlsHigh endemicityLeptospirosisFocused interventionsMore ratsSyndromeRatsEpidemicEnvironmental sourcesComplicationsFactorsMortality