2021
A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus
Wunder EA, Adhikarla H, Hamond C, Bonner K, Liang L, Rodrigues CB, Bisht V, Nally JE, Alt DP, Reis MG, Diggle PJ, Felgner PL, Ko A. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus. ELife 2021, 10: e64166. PMID: 33496263, PMCID: PMC7837694, DOI: 10.7554/elife.64166.Peer-Reviewed Original ResearchConceptsCross-protective immunityPathogenic Leptospira speciesTerms of morbidityLeptospira speciesTransient bacteremiaSingle doseAntibody responseImmune responseApplicable vaccinesVaccine candidatesAnimal modelsEffective preventionAttenuated mutantsZoonotic diseaseLeptospira genusPotential correlatesDisease transmissionDiseaseLeptospirosisImmunityBacteremiaMorbidityImmunizationVaccineRelevant proteins
2008
Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums
Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums. PLOS Neglected Tropical Diseases 2008, 2: e228. PMID: 18431445, PMCID: PMC2292260, DOI: 10.1371/journal.pntd.0000228.Peer-Reviewed Original ResearchConceptsLeptospira antibodiesLeptospira infectionRisk factorsIndependent risk factorSocioeconomic statusUrban slumsCommunity-based surveyPopulation-based informationHousehold environmental factorsPoisson regression modelsBlack raceOverall prevalencePrior infectionHealth outcomesHealth problemsUrban leptospirosisInfection riskInfectionSocial gradientUnequal health outcomesEffective preventionLeptospira transmissionTransmission determinantsAntibodiesSystem survey