2022
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
2008
Rescue of a Living Donor with Liver Transplantation
Ringe B, Xiao G, Sass D, Karam J, Shang S, Maroney T, Trebelev A, Levison S, Fuchs A, Petrucci R, Ko A, Gonzalez M, Reynolds J, Meyers W. Rescue of a Living Donor with Liver Transplantation. American Journal Of Transplantation 2008, 8: 1557-1561. PMID: 18510644, DOI: 10.1111/j.1600-6143.2008.02261.x.Peer-Reviewed Original ResearchConceptsLiver failureOnly life-saving treatmentDonor liver resectionPostoperative liver failureMultiple organ failureLiving liver donorsLife-saving treatmentLiver transplantLiver transplantationPostoperative complicationsRight hemihepatectomyLiver resectionRare complicationOrgan failureCase reportLiver donorsHealthy donorsTimely transplantationOwn patientsPatientsComplicationsTransplantationOnly survivorFailureDonors