2015
Tissue instruction for migration and retention of TRM cells
Iijima N, Iwasaki A. Tissue instruction for migration and retention of TRM cells. Trends In Immunology 2015, 36: 556-564. PMID: 26282885, PMCID: PMC4567393, DOI: 10.1016/j.it.2015.07.002.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsMemory lymphocyte clustersTRM cellsT cellsCD4 tissue-resident memory T cellsRobust local immune responseCD8 TRM cellsEffector T cellsLocal immune responseMemory T cellsNon-lymphoid tissuesLymphocyte clustersImmune responseInfectious agentsIncoming pathogensCell homingRecent findingsCellsInfectionFindings
2008
The autophagy gene ATG5 plays an essential role in B lymphocyte development
Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008, 4: 309-314. PMID: 18188005, DOI: 10.4161/auto.5474.Peer-Reviewed Original ResearchConceptsB cell developmentCell developmentGene ATG5Pre-B cell transitionB lymphocyte developmentDeletion of Atg5Fetal liver progenitorsAutophagy gene ATG5B cell survivalCell lineagesCell transitionLymphocyte developmentCell survivalB-1a B cellsCell deathCre-loxP technologyCytoplasmic constituentsATG5Liver progenitorsEssential roleSignificant defectsB cellsDiscrete stagesCell numberCells