2014
Application of the Proximity-Dependent Assay and Fluorescence Imaging Approaches to Study Viral Entry Pathways
Lipovsky A, Zhang W, Iwasaki A, DiMaio D. Application of the Proximity-Dependent Assay and Fluorescence Imaging Approaches to Study Viral Entry Pathways. Methods In Molecular Biology 2014, 1270: 437-451. PMID: 25702134, DOI: 10.1007/978-1-4939-2309-0_30.Peer-Reviewed Original ResearchConceptsGenome-wide RNA interference screenEnriched gene categoriesConfirmation of phenotypesGenome-wide lossRNA interference screenVirus entryFunction genetic screenRNA interference studiesFluorescence imaging approachesProximity ligation assayGenetic screenGene categoriesInterference screenMembrane compartmentsIndividual genesBiochemical approachesCellular compartmentsMolecular intricaciesMicroscopy-based methodBioinformatics analysisProtein locationRNA interferenceCellular organellesViral entry pathwayCellular factors
2011
Autophagy in the control and pathogenesis of viral infection
Yordy B, Iwasaki A. Autophagy in the control and pathogenesis of viral infection. Current Opinion In Virology 2011, 1: 196-203. PMID: 21927636, PMCID: PMC3171969, DOI: 10.1016/j.coviro.2011.05.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyHumansImmunity, InnateVirus DiseasesVirus Physiological PhenomenaVirusesConceptsEukaryotic defense mechanismEukaryotic cell metabolismIntracellular pathogensVertebrate immune systemTime of starvationConstitutive autophagyCellular proteinsKey unanswered questionsCell metabolismAncient abilityAutophagyDefense mechanismsCell processesAntiviral immune responseRecent findingsPathogensCentral roleViral pathogensImmune systemOrganellesViral infectionMachineryUnanswered questionsImmune responseProteinGenome–virome interactions: examining the role of common viral infections in complex disease
Foxman EF, Iwasaki A. Genome–virome interactions: examining the role of common viral infections in complex disease. Nature Reviews Microbiology 2011, 9: 254-264. PMID: 21407242, PMCID: PMC3678363, DOI: 10.1038/nrmicro2541.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesHuman genetic variationLarge regulatory networkHost-virus interactionsCrohn's diseaseRegulatory networksHost genesGenetic variationModel hostGenomic technologiesAutophagy pathwayAntiviral defenseViral infectionAdditional host factorsEnvironmental conditionsComplex diseasesCommon viral infectionsCases of asthmaSubsequent disease developmentGenesHostHost factorsDisease developmentParticular virus