2017
Immune Regulation of Antibody Access to Neuronal Tissues
Iwasaki A. Immune Regulation of Antibody Access to Neuronal Tissues. Trends In Molecular Medicine 2017, 23: 227-245. PMID: 28185790, PMCID: PMC5626569, DOI: 10.1016/j.molmed.2017.01.004.Peer-Reviewed Original ResearchConceptsBlood-brain barrierBlood-nerve barrierAdaptive immune systemImmune systemAntibody accessInnate immune controlUse of vaccinesImmune controlNeurotropic virusesCancer immunotherapyImmune regulationImmune surveillanceT cellsTAM receptorsNeurodegenerative conditionsAlzheimer's diseaseNeuronal tissueNeural tissueDiseaseTissueNovel insightsSuch novel insightsImmunotherapyCD4Cells
2015
Control of adaptive immunity by the innate immune system
Iwasaki A, Medzhitov R. Control of adaptive immunity by the innate immune system. Nature Immunology 2015, 16: 343-353. PMID: 25789684, PMCID: PMC4507498, DOI: 10.1038/ni.3123.Peer-Reviewed Original Research
2014
Application of the Proximity-Dependent Assay and Fluorescence Imaging Approaches to Study Viral Entry Pathways
Lipovsky A, Zhang W, Iwasaki A, DiMaio D. Application of the Proximity-Dependent Assay and Fluorescence Imaging Approaches to Study Viral Entry Pathways. Methods In Molecular Biology 2014, 1270: 437-451. PMID: 25702134, DOI: 10.1007/978-1-4939-2309-0_30.Peer-Reviewed Original ResearchConceptsGenome-wide RNA interference screenEnriched gene categoriesConfirmation of phenotypesGenome-wide lossRNA interference screenVirus entryFunction genetic screenRNA interference studiesFluorescence imaging approachesProximity ligation assayGenetic screenGene categoriesInterference screenMembrane compartmentsIndividual genesBiochemical approachesCellular compartmentsMolecular intricaciesMicroscopy-based methodBioinformatics analysisProtein locationRNA interferenceCellular organellesViral entry pathwayCellular factors
2013
Tissue‐resident memory T cells
Shin H, Iwasaki A. Tissue‐resident memory T cells. Immunological Reviews 2013, 255: 165-181. PMID: 23947354, PMCID: PMC3748618, DOI: 10.1111/imr.12087.Peer-Reviewed Original ResearchConceptsMemory T cellsHuman immunodeficiency virusHerpes simplex virusGenital tractT cellsPeripheral tissuesImmune systemTissue-resident memory T cellsMemory T cell migrationTissue-resident memory cellsT cell-based vaccinesMemory T cell populationsMemory T cell subsetsAntibody-based vaccinesT cell recruitmentT cell subsetsNew vaccination strategiesT cell populationsSecondary lymphoid organsNon-lymphoid tissuesPortal of entryT cell migrationAdaptive immune systemTRM cellsEffector memory
2012
A Virological View of Innate Immune Recognition
Iwasaki A. A Virological View of Innate Immune Recognition. Annual Review Of Microbiology 2012, 66: 177-196. PMID: 22994491, PMCID: PMC3549330, DOI: 10.1146/annurev-micro-092611-150203.Peer-Reviewed Original ResearchAutophagy and selective deployment of Atg proteins in antiviral defense
Yordy B, Tal MC, Hayashi K, Arojo O, Iwasaki A. Autophagy and selective deployment of Atg proteins in antiviral defense. International Immunology 2012, 25: 1-10. PMID: 23042773, PMCID: PMC3534236, DOI: 10.1093/intimm/dxs101.Peer-Reviewed Original ResearchConceptsAutophagy machineryAtg proteinsAntiviral defenseViral pathogen-associated molecular patternsPathogen-associated molecular patternsEukaryotic cellsCellular homeostasisCanonical autophagyViral replication sitesMajor histocompatibility complex presentationIntracellular transportAntiviral proteinCytosolic componentsRegulatory functionsEndolysosomal compartmentsReplication sitesAutophagyMachineryMolecular patternsDiverse repertoireIntracellular materialProteinToll-like receptorsViral antigen processingSelective targeting
2011
Autophagy in the control and pathogenesis of viral infection
Yordy B, Iwasaki A. Autophagy in the control and pathogenesis of viral infection. Current Opinion In Virology 2011, 1: 196-203. PMID: 21927636, PMCID: PMC3171969, DOI: 10.1016/j.coviro.2011.05.016.Peer-Reviewed Original ResearchConceptsEukaryotic defense mechanismEukaryotic cell metabolismIntracellular pathogensVertebrate immune systemTime of starvationConstitutive autophagyCellular proteinsKey unanswered questionsCell metabolismAncient abilityAutophagyDefense mechanismsCell processesAntiviral immune responseRecent findingsPathogensCentral roleViral pathogensImmune systemOrganellesViral infectionMachineryUnanswered questionsImmune responseProtein
2008
Autophagy and antiviral immunity
Lee HK, Iwasaki A. Autophagy and antiviral immunity. Current Opinion In Immunology 2008, 20: 23-29. PMID: 18262399, PMCID: PMC2271118, DOI: 10.1016/j.coi.2008.01.001.Peer-Reviewed Original ResearchConceptsViral infectionViral replicationAdaptive antiviral immune responsesEndogenous viral antigensCD4 T cellsMHC class II loading compartmentsAntiviral immune responseCritical effector mechanismAdaptive immune systemViral antigensEffector mechanismsT cellsImmune responseAntiviral immunityImmune systemLoading compartmentCertain virusesInfectionAutophagyRecent studiesCellsAntigenImmunityCellular homeostasis
2007
Toll-like receptors regulation of viral infection and disease
Thompson JM, Iwasaki A. Toll-like receptors regulation of viral infection and disease. Advanced Drug Delivery Reviews 2007, 60: 786-794. PMID: 18280610, PMCID: PMC2410298, DOI: 10.1016/j.addr.2007.11.003.Peer-Reviewed Original ResearchConceptsToll-like receptorsVirus infectionRole of TLRsProtective anti-viral immunityToll-like receptor regulationAdaptive immune responsesAnti-viral immunityMammalian Toll-like receptorsVirus-induced diseaseViral nucleic acidsStudies of miceTLR activationInteraction of virusImmune responseViral infectionTLR systemTLR proteinsReceptor regulationInfectionDiseaseOutcomesCritical roleMiceImmunityReceptors