2010
Inflammasomes as mediators of immunity against influenza virus
Pang IK, Iwasaki A. Inflammasomes as mediators of immunity against influenza virus. Trends In Immunology 2010, 32: 34-41. PMID: 21147034, PMCID: PMC3017631, DOI: 10.1016/j.it.2010.11.004.Peer-Reviewed Original ResearchConceptsToll-like receptor 7Influenza virusMediators of immunityInfluenza virus infectionHuman respiratory infectionsRetinoic acid-inducible gene IAcid-inducible gene IInducible gene IInnate immune systemAdaptive immune defenseEndosomal recognitionInnate detectionRespiratory infectionsReceptor 7Virus infectionCytosolic recognitionInflammasome activationLike receptorsImmune systemImmune defenseMajor causeGene IVirusSuch activationMultiple mechanisms
2004
Toll-like receptor control of the adaptive immune responses
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 2004, 5: 987-995. PMID: 15454922, DOI: 10.1038/ni1112.Peer-Reviewed Original ResearchConceptsToll-like receptorsAdaptive immune responsesImmune responseMechanisms of TLRToll-like receptor controlHost defense responsesDendritic cell functionDendritic cell populationsMicrobial infectionsInnate immune systemDistinct anatomical locationsInflammatory reactionAdaptive immunityImmune systemAnatomical locationReceptor controlCell functionCell populationsMultiple mechanismsInfectionRecent studiesResponseInitiationSystemic defenseImportant clues