2018
KDM5 histone demethylases repress immune response via suppression of STING
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLOS Biology 2018, 16: e2006134. PMID: 30080846, PMCID: PMC6095604, DOI: 10.1371/journal.pbio.2006134.Peer-Reviewed Original ResearchConceptsImmune responseSTING expressionCyclic GMP-AMP synthase stimulatorSuppression of STINGCancer cellsCancer immunotherapy agentsHuman papilloma virusAdaptive immune responsesMultiple clinical trialsExpression of STINGBreast cancer cellsInnate immune defenseRobust interferon responseMultiple cancer typesIntratumoral CD8Immunotherapy agentsAnticancer immunotherapyPatient survivalNeck cancerPapilloma virusClinical trialsT cellsSTING agonistsKDM5 histonePositive head
2008
Dendritic cells and macrophages in the genitourinary tract
Iijima N, Thompson J, Iwasaki A. Dendritic cells and macrophages in the genitourinary tract. Mucosal Immunology 2008, 1: 451-459. PMID: 19079212, PMCID: PMC2684461, DOI: 10.1038/mi.2008.57.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsDendritic cellsGenitourinary tractGU tractUnderstanding of DCsSubsets of DCsImmune defenseFemale genital mucosaInnate immune defenseGenital mucosaMaternal toleranceSex hormonesAdaptive immunityReproductive functionMacrophagesTractNumerous agentsSTIsImportant reproductive functionsCellsDivergent rolesMucosaFetusesInfectionHormone