2017
The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry
Lipovsky A, Erden A, Kanaya E, Zhang W, Crite M, Bradfield C, MacMicking J, DiMaio D, Schoggins JW, Iwasaki A. The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry. Journal Of General Virology 2017, 98: 2821-2836. PMID: 29058661, PMCID: PMC5845663, DOI: 10.1099/jgv.0.000954.Peer-Reviewed Original ResearchConceptsHuman papillomavirusEntry of HPVVirus entryImportant infectious causeL1 major capsid proteinHPV typesTrans-Golgi networkInfectious causesProphylactic vaccinesHPV16 infectionL2 minor capsid proteinHPV entryDeadly cancerHPV16 entryBasal levelsInfectionVirus uptakeRetrograde transportHuman keratinocytesCapsid proteinHPV16PapillomavirusVirus uncoatingNon-enveloped virusesVirus
2015
No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing
Saglam O, Samayoa E, Somasekar S, Naccache S, Iwasaki A, Chiu CY. No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing. PLOS ONE 2015, 10: e0125292. PMID: 25894343, PMCID: PMC4404153, DOI: 10.1371/journal.pone.0125292.Peer-Reviewed Original ResearchConceptsVulvar squamous cell carcinomaVulvar intraepithelial neoplasiaDVIN casesHuman papillomavirusHigh-grade vulvar intraepithelial neoplasiaUsual-type vulvar intraepithelial neoplasiaUsual-type VINSquamous cell carcinomaHPV infectionIntraepithelial neoplasiaCell carcinomaPrecursor lesionsSmall biopsiesInfectious agentsDifferentiated typeGermline mutationsP53 geneInfectionDVINBiopsyCarcinomaPapillomavirusNeoplasiaLesionsCases
2013
High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells
Iijima N, Goodwin EC, DiMaio D, Iwasaki A. High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology 2013, 444: 257-262. PMID: 23871219, PMCID: PMC3755085, DOI: 10.1016/j.virol.2013.06.020.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusLangerhans cellsHigh-risk HPVCompetent antigen presenting cellsHPV-positive cancer cellsKey antigen-presenting cellsHPV-positive cervical cancer cellsCancer cellsHuman peripheral blood monocytesAntigen-presenting cellsAntigen presenting cellsImmune evasion strategiesPeripheral blood monocytesVariety of malignanciesCervical cancer cellsContact-dependent mannerDifferentiation of monocytesHuman papillomavirusPresenting cellsImmune surveillanceSquamous epitheliumBlood monocytesMucosal epitheliumHPV E6HPV16 E6
2012
Unique features of antiviral immune system of the vaginal mucosa
Kumamoto Y, Iwasaki A. Unique features of antiviral immune system of the vaginal mucosa. Current Opinion In Immunology 2012, 24: 411-416. PMID: 22673876, PMCID: PMC3423557, DOI: 10.1016/j.coi.2012.05.006.Peer-Reviewed Original ResearchConceptsVaginal mucosaVirus-specific CD4Development of vaccinesAntiviral immune systemHuman papillomavirusGenital tractT cellsImmune responseAdaptive immunityHuman vaccinesMucosal organsImmune systemVaccineAntiviral defenseMucosaVaginaVirusRecent studiesWide spectrumVast majorityCurrent understandingCD8CD4PapillomavirusImmunobiology
2010
Antiviral immune responses in the genital tract: clues for vaccines
Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nature Reviews Immunology 2010, 10: 699-711. PMID: 20829886, PMCID: PMC3678359, DOI: 10.1038/nri2836.Peer-Reviewed Original ResearchConceptsGenital mucosaT cellsGenital tractHerpes simplex virus type 2Simplex virus type 2Innate immune cellsT cell populationsAntiviral immune responseFemale genital tractPattern recognition receptorsVirus type 2Immune correlatesMemory CD4Memory CD8Viral clearanceHuman papillomavirusImmune cellsMemory lymphocytesSuccessful vaccineHIV-1Immune responseSevere diseaseVaginal epitheliumAdaptive immunityTarget cell type