2016
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
Graf F, Ludin P, Arquint C, Schmidt R, Schaub N, Kunz Renggli C, Munday J, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning H, Mäser P. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular And Molecular Life Sciences 2016, 73: 3387-3400. PMID: 26973180, PMCID: PMC4967103, DOI: 10.1007/s00018-016-2173-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAquaporinsComparative Genomic HybridizationDNA, ProtozoanDrug ResistanceGenome, ProtozoanHeterozygoteHumansMaleMelarsoprolNucleoside Transport ProteinsParasitic Sensitivity TestsPentamidinePhenotypePolymorphism, Single NucleotideProtozoan ProteinsRNA-Binding ProteinsSequence AlignmentTrypanocidal AgentsTrypanosoma brucei rhodesienseTrypanosomiasis, African
2008
Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa
Santolamazza F, Calzetta M, Etang J, Barrese E, Dia I, Caccone A, Donnelly M, Petrarca V, Simard F, Pinto J, della Torre A. Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa. Malaria Journal 2008, 7: 74. PMID: 18445265, PMCID: PMC2405802, DOI: 10.1186/1475-2875-7-74.Peer-Reviewed Original ResearchConceptsL1014F alleleVoltage-gated sodium channel geneM-form populationsSodium channel geneResistance allele frequencyAnopheles gambiae sensu strictoPhenotypic effectsGambiae sensu strictoSelection pressureGambiae ML1014F mutationMolecular formsPosition 1014Channel genesL1014S mutationS formLigation assayL1014S alleleSensu strictoKdr genotypesVector speciesKdr alleleAllele-specific PCRPoint mutationsFormer mutation