SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma
Chen H, Gao S, Wang P, Xie M, Zhang H, Fan Y, Nie E, Lan Q. SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma. Environmental Toxicology 2024 PMID: 39258423, DOI: 10.1002/tox.24396.Peer-Reviewed Original ResearchRNA-binding proteinsP53 signalingInhibits Mdm2-mediated p53 ubiquitinationMDM2-mediated p53 ubiquitinationRPL11-MDM2-p53 pathwayElevated p53 levelsRibosomal protein expressionBinding to MDM2Tumor-associated macrophagesP53 signaling pathwayInactivation of p53P53 ubiquitinationRibosomal proteinsRNA translationM2 macrophage polarizationP53 levelsTumor growthRPL11Mouse xenograft modelEctopic expressionGlioma tumor growthCell cycleBinding proteinTarget genesSignaling pathway