2023
Exposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children
Vilhelmsson A, Rylander L, Jöud A, Lindh C, Mattsson K, Liew Z, Guo P, Ritz B, Källén K, Thacher J. Exposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children. The Science Of The Total Environment 2023, 899: 165622. PMID: 37474063, DOI: 10.1016/j.scitotenv.2023.165622.Peer-Reviewed Original ResearchConceptsOdds ratioPreterm infantsEarly pregnancyPerfluorononanoic acidPrenatal PFAS exposureMaternal serum concentrationsCerebral palsy casesConfidence intervalsCase-control studyRisk of CPEnvironmental risk factorsPositive associationContinuous variablesHigh PFASPalsy casesBirth RegistryPreterm controlsCerebral palsyLifestyle factorsPreterm casesUnexplained etiologyPrenatal exposureSerum concentrationsRisk factorsPerfluorooctane sulfonate
2018
Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort
Meng Q, Inoue K, Ritz B, Olsen J, Liew Z. Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort. International Journal Of Environmental Research And Public Health 2018, 15: 1832. PMID: 30149566, PMCID: PMC6164159, DOI: 10.3390/ijerph15091832.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortLow birth weightNational Birth CohortBirth weightPreterm birthBirth outcomesPFASs exposureBirth cohortPrenatal PFASs exposureMaternal plasma concentrationsAdverse birth outcomesPerfluorononanoic acidPerfluorodecanoic acidWidespread industrial pollutantsPerfluoroalkyl substancesPerfluorooctanoate exposureGestational ageHighest quartileInfant pairsEarly pregnancyFetal growthPrenatal exposurePerfluoroheptane sulfonatePlasma concentrationsElevated riskPrenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort
Liew Z, Ritz B, Bach CC, Asarnow RF, Bech BH, Nohr EA, Bossi R, Henriksen TB, Bonefeld-Jørgensen EC, Olsen J. Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort. Environmental Health Perspectives 2018, 126: 067004. PMID: 29897723, PMCID: PMC6084884, DOI: 10.1289/ehp2754.Peer-Reviewed Original ResearchDevelopmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes
Liew Z, Goudarzi H, Oulhote Y. Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes. Current Environmental Health Reports 2018, 5: 1-19. PMID: 29556975, PMCID: PMC6348874, DOI: 10.1007/s40572-018-0173-4.Peer-Reviewed Original ResearchConceptsHealth outcomesPostnatal growthAssociated health outcomesPurpose of ReviewWePerfluoroalkyl substancesPlacenta transferBirth outcomesPotential health effectsPostnatal exposureImmunomodulatory effectsPrenatal exposureEpidemiological evidenceEpidemiological findingsDevelopmental exposureImmune functionAnimal studiesPossible associationNeurodevelopmental endpointsAdverse effectsHealth effectsHuman exposureOutcomesExposureBreastfeedingHome environment
2015
Bias from conditioning on live birth in pregnancy cohorts: an illustration based on neurodevelopment in children after prenatal exposure to organic pollutants
Liew Z, Olsen J, Cui X, Ritz B, Arah OA. Bias from conditioning on live birth in pregnancy cohorts: an illustration based on neurodevelopment in children after prenatal exposure to organic pollutants. International Journal Of Epidemiology 2015, 44: 345-354. PMID: 25604449, PMCID: PMC4339763, DOI: 10.1093/ije/dyu249.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderLive birthsPrenatal exposurePregnancy cohortFetal lossDanish National Birth CohortLong-term health outcomesNational Birth CohortWeak inverse associationEarly fetal lossPerfluoroalkyl substancesPregnancy lossSchool-aged childrenInverse associationFetal survivalCommon causeObservational studyBirth cohortHealth outcomesHuman fecundityCohortHyperactivity disorderBirthOutcomesNeurodevelopment
2014
Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort
Liew Z, Ritz B, von Ehrenstein OS, Bech BH, Nohr EA, Fei C, Bossi R, Henriksen TB, Bonefeld-Jørgensen EC, Olsen J. Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort. Environmental Health Perspectives 2014, 123: 367-373. PMID: 25616253, PMCID: PMC4383573, DOI: 10.1289/ehp.1408412.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDanish National Birth CohortNational Birth CohortDeficit/hyperactivity disorderPrenatal exposureRisk ratioChildhood autismBirth cohortDanish National Hospital RegistryDanish Psychiatric Central RegistryNested Case-Control StudyRisk of ADHDNational Hospital RegistryPrenatal PFAS exposureHyperactivity disorderCase-control studyMother-child pairsPerfluoroalkyl substancesConsistent evidenceHospital registryProspective studyPlasma levelsNeurobehavioral problemsPFAS exposureCentral RegistryPrenatal Exposure to Perfluoroalkyl Substances and the Risk of Congenital Cerebral Palsy in Children
Liew Z, Ritz B, Bonefeld-Jørgensen EC, Henriksen TB, Nohr EA, Bech BH, Fei C, Bossi R, von Ehrenstein OS, Streja E, Uldall P, Olsen J. Prenatal Exposure to Perfluoroalkyl Substances and the Risk of Congenital Cerebral Palsy in Children. American Journal Of Epidemiology 2014, 180: 574-581. PMID: 25139206, DOI: 10.1093/aje/kwu179.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlkanesulfonic AcidsCaprylatesCase-Control StudiesCerebral PalsyCohort StudiesDenmarkEndocrine DisruptorsEnvironmental MonitoringEnvironmental PollutantsFemaleFluorocarbonsHumansInfant, NewbornMaleMaternal AgeOdds RatioPregnancyPrenatal Exposure Delayed EffectsSex DistributionSex FactorsYoung AdultConceptsCongenital cerebral palsyPrenatal exposureCerebral palsyDanish National Birth CohortCerebral Palsy RegisterNational Birth CohortFetal brain developmentDose-response patternCase-cohort designPerfluoroalkyl substancesLiveborn singletonsMaternal levelsRisk ratioHigh riskCP casesCP riskBirth cohortMaternal plasmaBrain developmentPalsyPerfluorooctane sulfonateRiskPFAS levelsCohortPerfluorooctanoic acid