2021
Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet P, Joshi A, MacDonald E, Hutton B, Cheng W, Stevens A, Kanji S. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews. PLOS ONE 2021, 16: e0244966. PMID: 33481817, PMCID: PMC7822342, DOI: 10.1371/journal.pone.0244966.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial InfectionsBeta-LactamsHumansInfusions, IntravenousSystematic Reviews as TopicTreatment OutcomeConceptsBeta-lactam antimicrobialsClinical cureSystematic reviewProlonged infusionBeta-lactam infusionDefinitive systematic reviewLess sick patientsLength of stayCurrent systematic reviewOverview of reviewsEmergence of resistanceBeta-lactam antibioticsSubsequent systematic reviewsAdverse eventsMicrobiological cureHospitalized patientsIll patientsClinical outcomesIntermittent infusionTreatment failureDATA EXTRACTIONCochrane LibraryMethodologic qualityPROSPERO registryBias assessment
2019
Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis
Ahmadzai N, Cheng W, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Esmaeilisaraji L, Kilty S, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis. Systematic Reviews 2019, 8: 341. PMID: 31888735, PMCID: PMC6937806, DOI: 10.1186/s13643-019-1195-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultCanadaDepressionHearing LossHumansInterpersonal RelationsMaleMeniere DiseaseMeta-Analysis as TopicNetwork Meta-AnalysisQuality of LifeSystematic Reviews as TopicTinnitusVertigoConceptsSensorineural hearing lossMeniere's diseaseQuality of lifeSystematic reviewHearing-related disabilitySeverity of vertigoAttacks of vertigoIntractable Meniere's diseaseKey clinical trialsIntensity of tinnitusPre-specified eligibility criteriaCause of disabilityClinical treatment strategiesPlanned systematic reviewElectronic search strategyOptimal clinical treatment strategiesMedical information specialistBackgroundHearing lossVertigo attacksCochrane riskSurgical therapyBias toolSurgical interventionCochrane LibraryFuture trials