Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?
Thiruganasambandamoorthy V, McRae AD, Rowe BH, Sivilotti MLA, Mukarram M, Nemnom MJ, Booth RA, Calder LA, Stiell IG, Wells GA, Cheng W, Taljaard M. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope? Annals Of Internal Medicine 2020, 172: 648-655. PMID: 32340039, DOI: 10.7326/m19-3515.Peer-Reviewed Original ResearchConceptsCanadian Syncope Risk ScoreSerious adverse eventsPro-B-type natriuretic peptideSerum NT-proBNP concentrationNT-proBNP concentrationsNT-proBNPNatriuretic peptideED patientsN-terminal pro-B-type natriuretic peptideTerminal pro-B-type natriuretic peptidePhysicians Services Incorporated FoundationIndex ED visitNT-proBNP valuesAdult ED patientsProspective cohort studySerum NT-proBNPEmergency department patientsNet reclassification indexHeterogeneity of outcomesAdjudication of outcomesNoncardiac eventsED dispositionAdverse eventsCohort studyComposite outcomeImpact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation
Bhatt M, Cheng W, Roback MG, Johnson DW, Taljaard M, Canada T. Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation. Academic Emergency Medicine 2020, 27: 217-227. PMID: 31894606, DOI: 10.1111/acem.13913.Peer-Reviewed Original ResearchConceptsPositive pressure ventilationOxygen desaturationOpioid administrationAdverse eventsSedation-related adverse eventsCanadian pediatric EDsPrimary risk factorImpact of timingOpioid typeSedation medicationsRespiratory depressionProspective cohortPediatric EDPressure ventilationSedative agentsOriginal cohortProcedural sedationRisk factorsPainful proceduresProcedure typeSedation outcomesMultivariable regressionOpioidsHigh incidenceSedationPre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. The BMJ 2019, 367: l6373. PMID: 31801749, PMCID: PMC6891802, DOI: 10.1136/bmj.l6373.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestPrognostic factorsSystematic reviewReduced oddsPrimary analysisInitial shockable rhythmIntra-arrest factorsPre-arrest factorsHigh-certainty evidenceChronic kidney diseaseDuration of resuscitationRisk of biasEnglish-language studiesWeb of ScienceActive malignancyCertainty evidenceCohort studyGRADE approachOdds of survivalCochrane DatabaseMale sexKidney diseaseShockable rhythmRelevant confounders