A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Moher D, Hutton B. A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PLOS ONE 2019, 14: e0221713. PMID: 31498809, PMCID: PMC6733451, DOI: 10.1371/journal.pone.0221713.Peer-Reviewed Original ResearchConceptsIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossSensorineural hearing lossPTA improvementSystemic steroidsHearing recoveryHearing lossHigh riskManagement of ISSNHLSystematic reviewPure-tone average improvementSystemic steroid treatmentCause of disabilityExperienced information specialistSelection of treatmentQuality of lifeMajority of casesRemoval of duplicatesIntratympanic steroidsIntravenous steroidsIT steroidsOral steroidsPharmacologic therapySteroid treatmentActive treatmentDiagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.
Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE. Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review. Journal Of Bone And Joint Surgery 2019, 101: 635-649. PMID: 30946198, DOI: 10.2106/jbjs.18.00632.Peer-Reviewed Original ResearchConceptsChronic periprosthetic joint infectionPeriprosthetic joint infectionHigh riskTissue-based testsJoint infectionKnee replacementSystematic reviewC-reactive protein levelsWhite blood cell countDiagnostic accuracyDiagnostic testsDiagnostic Accuracy Studies-2 toolShort-term mortalityBlood cell countPolymorphonuclear neutrophil percentageAlpha-defensin testLeukocyte esterase reagent stripsTotal joint replacementHierarchical summary receiverDiagnostic test resultsDevastating complicationPeer-reviewed journalsNeutrophil percentagePoor outcomeCochrane Library