2003
Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women
Morton L, Holford T, Leaderer B, Boyle P, Zahm S, Zhang Y, Flynn S, Tallini G, Zhang B, Owens P, Zheng T. Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women. British Journal Of Cancer 2003, 89: 2087-2092. PMID: 14647142, PMCID: PMC2376853, DOI: 10.1038/sj.bjc.6601388.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesFemaleHumansLymphoma, Non-HodgkinMiddle AgedRiskSmokingSurveys and QuestionnairesConceptsNon-Hodgkin lymphomaCumulative lifetime exposureCurrent smoking statusCigarette smokingNHL subtypesFollicular lymphomaLifetime exposurePopulation-based case-control studyRisk of NHLEtiology of NHLNon-Hodgkin lymphoma subtypesDuration of smokingIntensity of smokingPrevious epidemiologic studiesCase-control studyPopulation-based controlsHistologic typeSmoking statusIncident casesTumor gradeLymphoma subtypesEpidemiologic studiesSmokingImmunologic typeLymphomaGlutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingBreast NeoplasmsCase-Control StudiesEthanolFemaleGlutathione TransferaseHumansPolymorphism, GeneticRisk FactorsConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsCase-Control StudiesFemaleHumansNeoplasms, Radiation-InducedRisk FactorsConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCase-Control StudiesConnecticutFacultyFemaleHumansLibrariansMiddle AgedOccupational ExposureRisk Factors
2001
Lactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsCase-Control StudiesConnecticutFemaleHumansIncidenceLactationMiddle AgedOdds RatioRisk AssessmentTime FactorsConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Laden F, Collman G, Iwamoto K, Alberg A, Berkowitz G, Freudenheim J, Hankinson S, Helzlsouer K, Holford T, Huang H, Moysich K, Tessari J, Wolff M, Zheng T, Hunter D. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies. Journal Of The National Cancer Institute 2001, 93: 768-775. PMID: 11353787, DOI: 10.1093/jnci/93.10.768.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskRisk factorsEffect modificationOdds ratioBreast cancer risk factorsElevated breast cancer riskAssess effect modificationBody mass indexCancer risk factorsConfidence intervalsPooled odds ratioPotential risk factorsPlasma/serum concentrationsAssociation of levelsLarge U.S. studiesRandom-effects modelCase patientsMass indexMiddle tertileFifth quintilePooled analysisControl subjectsSerum concentrations
2000
Food group intake and the risk of oral epithelial dysplasia in a United States population
Morse D, Pendrys D, Katz R, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes & Control 2000, 11: 713-720. PMID: 11065008, DOI: 10.1023/a:1008943904085.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesDietEpitheliumFemaleFoodHumansMaleMiddle AgedMouth NeoplasmsRisk FactorsUnited StatesConceptsOral epithelial dysplasiaFood group intakesGroup intakesEpithelial dysplasiaOdds ratio point estimateDairy food intakeFood frequency questionnaireOral Pathology LaboratoryCase-control studyRole of dietBread/cerealsConsumption of fruitsAspects of dietUnited States populationIncident casesOral cancerOral carcinogenesisHistopathologic diagnosisLate effectsFood intakeAppointment datePotential covariatesLogistic regressionTelephone interviewsPathology laboratoryBreast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls
Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, Carter D, Boyle P, Dubrow R, Archibeque-Engle S, Zahm SH. Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal Of Epidemiology 2000, 152: 50-58. PMID: 10901329, DOI: 10.1093/aje/152.1.50.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedBreast NeoplasmsCase-Control StudiesFemaleHumansMiddle AgedPolychlorinated BiphenylsRisk FactorsConceptsBreast cancer riskCancer riskCovariate-adjusted odds ratioBreast Cancer Risk AssociatedCase-control studyBreast cancer casesBreast adipose tissueMean tissue levelsCancer Risk AssociatedLowest tertileThird tertileBreast diseaseOdds ratioBreast cancerCancer casesConnecticut womenAdipose tissueFurther stratificationSignificant associationStudy participantsTissue levelsNonhormonal activitiesBody levelEnvironmental exposuresSpecific PCB congenersExposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotalOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levelsβ‐Benzene hexachloride in breast adipose tissue and risk of breast carcinoma
Zheng T, Holford T, Mayne S, Owens P, Ward B, Carter D, Dubrow R, Zahm S, Boyle P, Tessari J. β‐Benzene hexachloride in breast adipose tissue and risk of breast carcinoma. Cancer 1999, 85: 2212-2218. PMID: 10326700, DOI: 10.1002/(sici)1097-0142(19990515)85:10<2212::aid-cncr16>3.0.co;2-f.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedBreast NeoplasmsCarcinomaCase-Control StudiesFemaleHexachlorocyclohexaneHumansInsecticidesMiddle AgedParityRisk AssessmentConceptsBreast adipose tissueAdipose tissue levelsBreast carcinoma riskBreast carcinoma casesBreast carcinomaAdipose tissueCarcinoma casesCarcinoma riskTissue levelsBenign breast diseaseProgesterone receptor statusPatients age 40Association of exposurePrimary breast carcinomaLogistic regression modelsPostmenopausal womenMenopausal statusParous womenNulliparous womenReceptor statusHighest quartilePotential confoundersBreast diseaseΒ-benzene hexachlorideConnecticut women
1997
Mouthwash use and dentures in relation to oral epithelial dysplasia
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Mouthwash use and dentures in relation to oral epithelial dysplasia. Oral Oncology 1997, 33: 338-343. PMID: 9415333, DOI: 10.1016/s1368-8375(97)00019-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesDenturesFemaleHumansMaleMiddle AgedMouth MucosaMouth NeoplasmsMouthwashesPrecancerous ConditionsRisk FactorsConceptsOral epithelial dysplasiaMouthwash useEpithelial dysplasiaDenture useOdds ratioYears of dentureOral Pathology LaboratoryCase-control studyConditional logistic regressionCase-control pairsOED casesAppointment datePotential associationLogistic regressionTelephone interviewsExposure informationPathology laboratoryConfidence intervalsDysplasiaDenturesMouthwashRiskSmokingYearsSurgeonsRisk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study
Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997, 33: 82-85. PMID: 9231164, DOI: 10.1016/s0964-1955(96)00056-5.Peer-Reviewed Original ResearchConceptsTongue cancerCase-control studyTobacco smokingAlcohol drinkingRisk factorsCurrent smokersCigarette equivalentsQuitting smokingEffect modificationTobacco consumptionSmokingAlcohol consumptionNumber of casesSignificant associationCancerYoung populationRiskRecent studiesDrinkingDaysSmokersYearsStudyDiseaseWeeks
1996
Smoking and drinking in relation to oral epithelial dysplasia.
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Mayne S. Smoking and drinking in relation to oral epithelial dysplasia. Cancer Epidemiology Biomarkers & Prevention 1996, 5: 769-77. PMID: 8896887.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaOdds ratioMouthwash useDenture statusRisk factorsEpithelial dysplasiaDrinks/weekAdjusted odds ratioImportant risk factorOral Pathology LaboratoryStandardized telephone interviewCase-control studyPotential risk factorsConditional logistic regressionLevel of smokingCurrent smokingAlcohol intakeIncident casesSmoking cessationOral cancerExcess riskHistopathological diagnosisSmokingAppointment dateLogistic regressionMalignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis
Chen Y, Dubrow R, Holford T, Zheng T, Barnhill R, Fine J, Berwick M. Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis. International Journal Of Cancer 1996, 67: 636-643. PMID: 8782651, DOI: 10.1002/(sici)1097-0215(19960904)67:5<636::aid-ijc8>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsMelanoma risk factorsCase-control studyRisk factorsAnatomic sitesSun exposurePopulation-based case-control studySun exposure-related factorsIntermittent sun exposureHistory of sunburnOnly risk factorPolychotomous logistic regression analysisInvasive melanoma casesNumber of neviLogistic regression analysisExposure-related factorsDevelopment of melanomaSex differencesPolychotomous logistic regressionHistologic subtypeMalignant melanomaClothing habitsPigmentary characteristicsMelanoma casesStudy subjectsLogistic regression
1995
Measurement of Exposure to Environmental Tobacco Smoke in Pregnant Women
O'Connor T, Holford T, Leaderer B, Hammond S, Bracken M. Measurement of Exposure to Environmental Tobacco Smoke in Pregnant Women. American Journal Of Epidemiology 1995, 142: 1315-1321. PMID: 7503052, DOI: 10.1093/oxfordjournals.aje.a117599.Peer-Reviewed Original ResearchConceptsUrine cotinineEnvironmental tobacco smokePregnant womenTobacco smokeWork exposureAir nicotine concentrationsSelf-reported exposurePersonal air monitorsExposure assessment methodsAir nicotineMeasurement of exposureHome exposureCotinineNicotine concentrationsExposure classificationWomenCohen's kappaExposureSpearman rank-order correlation coefficientAir monitorsRank-order correlation coefficientKappaSocial exposureSmokeHigh levels
1992
Risk Factors Predicting the Incidence of Second Primary Breast Cancer among Women Diagnosed with a First Primary Breast Cancer*
Bernstein J, Thompson W, Risch N, Holford T. Risk Factors Predicting the Incidence of Second Primary Breast Cancer among Women Diagnosed with a First Primary Breast Cancer*. American Journal Of Epidemiology 1992, 136: 925-936. PMID: 1456269, DOI: 10.1093/oxfordjournals.aje.a116565.Peer-Reviewed Original ResearchConceptsFirst primary breast cancerPrimary breast cancerSecond primary breast cancerContralateral breast cancerBreast cancerRisk factorsInitial tumorIncidence rateFirst primaryFirst prospective cohort studyAge-specific incidence ratesDirect patient interviewProspective cohort studySteroid Hormone StudySecond breast cancerEnd Results ProgramBenign breast biopsyProportional hazards modelSpecific risk factorsCohort studyTumor characteristicsLobular carcinomaResults ProgramPatient interviewsTreatment modalitiesThe Genetic Epidemiology of Second Primary Breast Cancer*
Bernstein J, Thompson W, Risch N, Holford T. The Genetic Epidemiology of Second Primary Breast Cancer*. American Journal Of Epidemiology 1992, 136: 937-948. PMID: 1456270, DOI: 10.1093/oxfordjournals.aje.a116566.Peer-Reviewed Original ResearchConceptsSecond primary breast cancerPrimary breast cancerContralateral breast cancerFirst primary breast cancerFirst-degree relativesBreast cancerFamily historyOvarian cancerMulti-center population-based case-control studyPopulation-based case-control studyAge-adjusted rate ratioSteroid Hormone StudyBilateral breast cancerEnd Results ProgramRate ratioCase-control studyCorresponding rate ratiosContralateral breastEndometrial cancerProspective studyResults ProgramSecond primaryCohort membersHigh riskHormone Study