2024
Projected health and economic effects of a pan-tuberculosis treatment regimen: a modelling study
Ryckman T, McQuaid C, Cohen T, Menzies N, Kendall E. Projected health and economic effects of a pan-tuberculosis treatment regimen: a modelling study. The Lancet Global Health 2024, 12: e1629-e1637. PMID: 39159654, PMCID: PMC11413512, DOI: 10.1016/s2214-109x(24)00284-5.Peer-Reviewed Original ResearchStandard of careInitial treatment attemptNewly diagnosed tuberculosis patientsTuberculosis burdenTreatment attemptDrug susceptibility testingProportion of patientsMechanisms of benefitNon-drug costsRifampicin susceptibilityTreatment discontinuationIncremental curingSusceptibility testingDrug susceptibilityRegimen developmentTreatment regimenTuberculosis patientsRegimenRegimensTuberculosis treatmentInjection regimensTuberculosis diagnosisRegimen assignmentsNon-adherenceSimulated cohortRacial and ethnic disparities in diagnosis and treatment outcomes among US-born people diagnosed with tuberculosis, 2003–19: an analysis of national surveillance data
Regan M, Li Y, Swartwood N, Barham T, Asay G, Cohen T, Hill A, Horsburgh C, Khan A, Marks S, Myles R, Salomon J, Self J, Menzies N. Racial and ethnic disparities in diagnosis and treatment outcomes among US-born people diagnosed with tuberculosis, 2003–19: an analysis of national surveillance data. The Lancet Public Health 2024, 9: e47-e56. PMID: 38176842, DOI: 10.1016/s2468-2667(23)00276-1.Peer-Reviewed Original ResearchConceptsNational surveillance dataNon-Hispanic White peopleTreatment outcomesEthnic disparitiesSurveillance dataTuberculosis diagnosisUS National Tuberculosis Surveillance SystemIndex of disparityLog-binomial regression modelsNational Tuberculosis Surveillance SystemNon-Hispanic black peopleOverall high riskTuberculosis Surveillance SystemAlaska Native peopleTuberculosis patientsDiagnostic delayAdverse outcomesTuberculosis diseaseTuberculosis incidence
2014
Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Galea J, Calderon R, Yataco R, Contreras C, Zhang ZB, Lecca L, Murray M. Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 1285-1291. PMID: 25299859, DOI: 10.5588/ijtld.14.0309.Peer-Reviewed Original ResearchConceptsLatent tuberculous infectionTuberculin skin testTB patientsIndex caseChild household contactsDrug-susceptible TBIndex TB patientsObservational cohort studySecondhand smoke exposureRisk of transmissionPoisson regression modelsHousehold contactsCohort studyTST positivityTuberculosis patientsTuberculous infectionSmoke exposureSmoking statusTuberculosis casesCigarette smokingSkin testRisk factorsPatientsInfection statusTime pointsAge-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Age-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting. American Journal Of Epidemiology 2014, 180: 853-861. PMID: 25190676, PMCID: PMC4188339, DOI: 10.1093/aje/kwu192.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionHousehold contactsAge-specific riskYears of ageTuberculosis infectionLarge population-based prospective cohort studyPopulation-based prospective cohort studyHousehold exposureBacillus Calmette-Guérin (BCG) vaccineIncident pulmonary tuberculosisCommunity exposureProspective cohort studyCalmette-Guérin vaccineHigh-burden settingsPublic Health CenterCommunity-based transmissionRisk of infectionCohort studyLTBI prevalencePreventive therapyPulmonary tuberculosisTuberculosis patientsTuberculosis casesHousehold transmissionExcess risk
2013
The Effect of HIV-Related Immunosuppression on the Risk of Tuberculosis Transmission to Household Contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Hughes KC, Zhang Z, Calderon R, Yataco R, Contreras C, Galea J, Lecca L, Murray M. The Effect of HIV-Related Immunosuppression on the Risk of Tuberculosis Transmission to Household Contacts. Clinical Infectious Diseases 2013, 58: 765-774. PMID: 24368620, PMCID: PMC3935504, DOI: 10.1093/cid/cit948.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHousehold contactsIndex patientsCD4 countTuberculosis patientsTuberculosis transmissionHIV-negative tuberculosis patientsHIV-negative patientsHIV-positive patientsDrug-sensitive tuberculosisTuberculin skin testingTuberculosis infection statusRisk of infectionCoinfected PatientsActive tuberculosisTuberculosis infectionHIV statusSkin testingImmunodeficiency virusRisk factorsRelative riskPatientsTuberculosisInfection statusInfectionIsoniazid-resistant Tuberculosis in Children
Yuen CM, Tolman AW, Cohen T, Parr JB, Keshavjee S, Becerra MC. Isoniazid-resistant Tuberculosis in Children. The Pediatric Infectious Disease Journal 2013, 32: e217-e226. PMID: 23348808, PMCID: PMC3709006, DOI: 10.1097/inf.0b013e3182865409.Peer-Reviewed Original ResearchConceptsIsoniazid-resistant tuberculosisLatent tuberculosis infectionTuberculosis diseaseTuberculosis infectionIsoniazid resistancePediatric tuberculosis patientsTreatment of childrenIsoniazid-resistant strainsReports of childrenEffective regimensTuberculosis patientsTuberculosis treatmentAppropriate treatmentInclusion criteriaMedian proportionSystematic reviewRifampin resistanceDiseaseTuberculosisRegimensChildrenTreatmentInfectionIsoniazidHigher proportionRisk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova
Jenkins HE, Ciobanu A, Plesca V, Crudu V, Galusca I, Soltan V, Cohen T. Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova. The International Journal Of Tuberculosis And Lung Disease 2013, 17: 373-380. PMID: 23407226, PMCID: PMC3710709, DOI: 10.5588/ijtld.12.0464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsContinuity of Patient CareFemaleHumansInstitutionalizationLeast-Squares AnalysisLinear ModelsMaleMedication AdherenceMoldovaMultivariate AnalysisPatient DischargePrisonersProportional Hazards ModelsRetrospective StudiesRisk FactorsSocioeconomic FactorsTime FactorsTreatment OutcomeTuberculosisConceptsMultidrug-resistant tuberculosisMDR-TB patientsRisk factorsHighest MDR-TB ratesDrug resistanceGreater lung pathologyMDR-TB ratesAnti-tuberculosis treatmentIndependent risk factorHuman immunodeficiency virusTB drug resistanceContinuity of careRoutine surveillance dataTuberculosis patientsResistant tuberculosisImmunodeficiency virusLung pathologyTreatment adherenceRetrospective analysisHigh riskPatientsSociodemographic factorsCommunity careSurveillance dataStudy period
2012
Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC
Lin HH, Shin SS, Contreras C, Asencios L, Paciorek CJ, Cohen T. Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 811-813. PMID: 22516236, PMCID: PMC3358052, DOI: 10.3201/eid1805.111467.Peer-Reviewed Original ResearchOutcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009.
Gegia M, Cohen T, Kalandadze I, Vashakidze L, Furin J. Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009. The International Journal Of Tuberculosis And Lung Disease 2012, 16: 812-6. PMID: 22507372, PMCID: PMC3786434, DOI: 10.5588/ijtld.11.0637.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsChi-Square DistributionDrug Resistance, BacterialDrug Therapy, CombinationEthambutolFemaleGeorgia (Republic)HumansIsoniazidLogistic ModelsMaleMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisMycobacterium tuberculosisPredictive Value of TestsPyrazinamideRetrospective StudiesRifampinRisk AssessmentRisk FactorsSputumTime FactorsTreatment OutcomeTuberculosisConceptsPulmonary tuberculosisPrevious treatmentOutcomes of patientsPulmonary TB patientsSubset of patientsRetrospective record reviewForms of tuberculosisFirst-line drugsHigh TB ratesDrug-resistant formsLower ratesLow tuberculosisTB patientsTuberculosis patientsOptimal management strategyTreatment regimenRecord reviewTB ratesTreatment successTreatment outcomesCountry of GeorgiaPatientsIsoniazid resistanceTuberculosisDrug resistance
2011
Models to understand the population-level impact of mixed strain M. tuberculosis infections
Sergeev R, Colijn C, Cohen T. Models to understand the population-level impact of mixed strain M. tuberculosis infections. Journal Of Theoretical Biology 2011, 280: 88-100. PMID: 21514304, PMCID: PMC3111980, DOI: 10.1016/j.jtbi.2011.04.011.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsMixed strain infectionsStrain infectionDrug-sensitive tuberculosisDrug-resistant tuberculosisM. tuberculosis infectionLower basic reproductive numberDrug-resistant infectionsTuberculosis patientsTuberculosis infectionTreatment successDrug-resistant bacteriaFuture burdenLong-term effectsStrain-specific differencesDrug resistanceInfectionPopulation-level impactTuberculosisM. tuberculosisMixed infectionsMycobacterium tuberculosisBasic reproductive numberCo-infected hostsSmall subpopulation
2010
Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study
Cohen T, Hedt BL, Pagano M. Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study. BMC Public Health 2010, 10: 355. PMID: 20565947, PMCID: PMC2898828, DOI: 10.1186/1471-2458-10-355.Peer-Reviewed Original Research