2013
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortality
2012
Oral Lesions: Poor Markers of Virologic Failure in HIV‐Infected Patients on Antiretroviral Therapy
Tami-Maury I, Willig J, Jolly P, Vermund S, Aban I, Hill J, Wilson C. Oral Lesions: Poor Markers of Virologic Failure in HIV‐Infected Patients on Antiretroviral Therapy. International Scholarly Research Notices 2012, 2013: 1-7. DOI: 10.5402/2013/269728.Peer-Reviewed Original ResearchPositive predictive valueVirologic failureAntiretroviral therapyPredictive valueViral loadHigh baseline viral loadMonths of ARTModerate positive predictive valueBaseline viral loadStrong positive predictive valueNegative predictive valueVirologic statusBaseline factorsCopies/Poor markerPatientsMental disordersOL groupTherapyMonthsHIVArt therapyPoor predictorMarkersFailure
2008
Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy
Goldman JD, Cantrell RA, Mulenga LB, Tambatamba BC, Reid SE, Levy JW, Limbada M, Taylor A, Saag MS, Vermund SH, Stringer JS, H. BH. Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy. AIDS Research And Human Retroviruses 2008, 24: 1031-1035. PMID: 18724803, PMCID: PMC2747786, DOI: 10.1089/aid.2008.0035.Peer-Reviewed Original ResearchConceptsMedication possession ratioVirologic failureOptimal adherenceSuboptimal adherenceTreatment failurePoor adherenceLow medication possession ratioDetectable HIV viremiaProportion of patientsSubset of patientsViral load measurementsART initiationHIV viremiaAntiretroviral therapyDetectable viremiaClinical responseDrug adherencePossession ratioMedian timeMissed doseImmunologic responseTreatment courseAdherence assessmentCopies/Patients