2021
Delayed production of neutralizing antibodies correlates with fatal COVID-19
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, PMCID: PMC8785364, DOI: 10.1038/s41591-021-01355-0.Peer-Reviewed Original ResearchConceptsDeceased patientsAntibody levelsAntibody responseDisease severityAnti-S IgG levelsCOVID-19 disease outcomesFatal COVID-19Impaired viral controlWorse clinical progressionWorse disease severitySevere COVID-19Length of hospitalizationImmunoglobulin G levelsHumoral immune responseCoronavirus disease 2019COVID-19 mortalityCOVID-19Domain (RBD) IgGSeroconversion kineticsDisease courseIgG levelsClinical parametersClinical progressionHumoral responseDisease onset
2001
Linkage disequilibrium in the human genome
Reich D, Cargill M, Bolk S, Ireland J, Sabeti P, Richter D, Lavery T, Kouyoumjian R, Farhadian S, Ward R, Lander E. Linkage disequilibrium in the human genome. Nature 2001, 411: 199-204. PMID: 11346797, DOI: 10.1038/35075590.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBiasChromosome MappingComputer SimulationEuropeFounder EffectGenetic Diseases, InbornGenome, HumanHaplotypesHeterozygoteHumansLinkage DisequilibriumModels, GeneticNigeriaPhylogenyPolymorphism, Single NucleotideRacial GroupsRecombination, GeneticReproducibility of ResultsSelection, GeneticTime FactorsUnited StatesConceptsLinkage disequilibriumGenome-wide mapsAncestral chromosomesGenomic regionsHuman genomeSingle nucleotide polymorphismsLD mappingDemographic eventsLD blocksCommon SNPsHuman geneticsNucleotide polymorphismsCommon allelesDifferent populationsAllelesNorth European descentDisequilibriumGenomeKilobasesChromosomesNorthern EuropeansGenesLociGeneticsKb