2018
Improved reference genome of Aedes aegypti informs arbovirus vector control
Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipović I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature 2018, 563: 501-507. PMID: 30429615, PMCID: PMC6421076, DOI: 10.1038/s41586-018-0692-z.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirus InfectionsArbovirusesDengue VirusDNA Copy Number VariationsFemaleGenetic VariationGenetics, PopulationGenome, InsectGenomicsGlutathione TransferaseInsect ControlInsecticide ResistanceMaleMolecular Sequence AnnotationMosquito VectorsMultigene FamilyPyrethrinsReference StandardsSex Determination ProcessesConceptsGenome assemblySex-determining M locusHigh-quality genome assemblyInsecticide resistancePopulation genomic analysesQuantitative trait lociGlutathione S-transferase geneEgg-laying sitesNew biological insightsDangerous viral pathogensCopy number variationsDengue vector competenceCytogenetic mapTrait lociReference genomeGenomic analysisBiological insightsDisease vectorsM locusFemale Aedes aegypti mosquitoesIonotropic receptorsVector competenceHuman hostAedes aegypti mosquitoesLoci
2006
Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome
Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D, Field M. Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome. MSphere 2006, 5: 1539-1549. PMID: 16963636, PMCID: PMC1563588, DOI: 10.1128/ec.00141-06.Peer-Reviewed Original ResearchConceptsOpen reading frameRNA interferenceGene functionChromosome IT. bruceiDrug targetsChromosome-wide analysisBloodstream form parasitesCell cycle progressionPotential drug targetsNew drug targetsTrypanosome genomeGrowth defectOrder KinetoplastidaGenome sequenceAffected cell growthI geneParasite biologyReading frameGene productsTrypanosoma bruceiBasic biologyParasitic organismsAfrican trypanosomesCycle progression