2021
Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements
Crava C, Varghese F, Pischedda E, Halbach R, Palatini U, Marconcini M, Gasmi L, Redmond S, Afrane Y, Ayala D, Paupy C, Carballar‐Lejarazu R, Miesen P, van Rij R, Bonizzoni M. Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements. Molecular Ecology 2021, 30: 1594-1611. PMID: 33432714, PMCID: PMC8048955, DOI: 10.1111/mec.15798.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsArboviral vector Aedes aegyptiEndogenous viral elementsPopulation genomicsGenomic architectureViral elementsVector Aedes aegyptiPiRNA-mediated silencingNonretroviral RNA virusesGenome-wide screenHorizontal gene transferSequence-specific mechanismWild-caught mosquitoesA. aegyptiEndogenization eventsAedes aegyptiAdaptive evolutionPiRNA clustersEukaryotic cellsGermline cellsTransposable elementsGeographical populationsHost genomeHost functionsCognate virus
2019
A chromosome-scale assembly of the major African malaria vector Anopheles funestus
Ghurye J, Koren S, Small S, Redmond S, Howell P, Phillippy A, Besansky N. A chromosome-scale assembly of the major African malaria vector Anopheles funestus. GigaScience 2019, 8: giz063. PMID: 31157884, PMCID: PMC6545970, DOI: 10.1093/gigascience/giz063.Peer-Reviewed Original ResearchConceptsReference genomeHigh-quality reference genomeCurrent reference assemblyHaploid genome sizeMajor African malaria vector Anopheles funestusN50 scaffold sizeChromosome-scale assemblyReference genome assemblyN50 contig sizeChromosome-scale scaffoldsMalaria vector Anopheles funestusAfrican malaria vector Anopheles funestusMbp of sequenceSingle-molecule sequencingPrimary assemblyAnopheles funestusHi-C dataImportant disease vectorChromosome scaffoldingGenome sizeGenome assemblyContig sizeReference assemblyGenomic variationAssociation of phenotypic
2018
Improved reference genome of Aedes aegypti informs arbovirus vector control
Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipović I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature 2018, 563: 501-507. PMID: 30429615, PMCID: PMC6421076, DOI: 10.1038/s41586-018-0692-z.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirus InfectionsArbovirusesDengue VirusDNA Copy Number VariationsFemaleGenetic VariationGenetics, PopulationGenome, InsectGenomicsGlutathione TransferaseInsect ControlInsecticide ResistanceMaleMolecular Sequence AnnotationMosquito VectorsMultigene FamilyPyrethrinsReference StandardsSex Determination ProcessesConceptsGenome assemblySex-determining M locusHigh-quality genome assemblyInsecticide resistancePopulation genomic analysesQuantitative trait lociGlutathione S-transferase geneEgg-laying sitesNew biological insightsDangerous viral pathogensCopy number variationsDengue vector competenceCytogenetic mapTrait lociReference genomeGenomic analysisBiological insightsDisease vectorsM locusFemale Aedes aegypti mosquitoesIonotropic receptorsVector competenceHuman hostAedes aegypti mosquitoesLoci
2013
The zebrafish reference genome sequence and its relationship to the human genome
Howe K, Clark M, Torroja C, Torrance J, Berthelot C, Muffato M, Collins J, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett J, Koch R, Rauch G, White S, Chow W, Kilian B, Quintais L, Guerra-Assunção J, Zhou Y, Gu Y, Yen J, Vogel J, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire S, Laird G, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliott D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley C, Ersan-Ürün Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberländer M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster S, Carter N, Harrow J, Ning Z, Herrero J, Searle S, Enright A, Geisler R, Plasterk R, Lee C, Westerfield M, de Jong P, Zon L, Postlethwait J, Nüsslein-Volhard C, Hubbard T, Crollius H, Rogers J, Stemple D. The zebrafish reference genome sequence and its relationship to the human genome. Nature 2013, 496: 498-503. PMID: 23594743, PMCID: PMC3703927, DOI: 10.1038/nature12111.Peer-Reviewed Original ResearchConceptsHigh-quality sequence assembliesHuman protein-coding genesProtein-coding genesReference genome sequenceKey genomic featuresHuman reference genomeZebrafish genomeZebrafish orthologueReference genomeGenome sequenceHuman genomeSequence assemblyGenomic featuresLarge genesGenomeGenesOrthologuesVertebratesSequenceAssembly
2011
VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics
Megy K, Emrich S, Lawson D, Campbell D, Dialynas E, Hughes D, Koscielny G, Louis C, MacCallum R, Redmond S, Sheehan A, Topalis P, Wilson D, . VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics. Nucleic Acids Research 2011, 40: d729-d734. PMID: 22135296, PMCID: PMC3245112, DOI: 10.1093/nar/gkr1089.Peer-Reviewed Original ResearchConceptsBioinformatics resourcesHigh-throughput dataPopulation geneticsTaxonomic coverageInsecticide resistance dataGenome browserGenomic variationInvertebrate vectorsGenomic featuresBiology resourcesExpression dataHuman pathogensTsetse fliesGenomeBody liceTimely releaseVectorBaseGenomicsGeneticsBioinformaticsFliesMultiple typesAnnotationLicePathogens
2008
VectorBase: a data resource for invertebrate vector genomics
Lawson D, Arensburger P, Atkinson P, Besansky N, Bruggner R, Butler R, Campbell K, Christophides G, Christley S, Dialynas E, Hammond M, Hill C, Konopinski N, Lobo N, MacCallum R, Madey G, Megy K, Meyer J, Redmond S, Severson D, Stinson E, Topalis P, Birney E, Gelbart W, Kafatos F, Louis C, Collins F. VectorBase: a data resource for invertebrate vector genomics. Nucleic Acids Research 2008, 37: d583-d587. PMID: 19028744, PMCID: PMC2686483, DOI: 10.1093/nar/gkn857.Peer-Reviewed Original ResearchConceptsBody louse Pediculus humanusBioinformatics Resource CenterCommunity annotation systemGene expression repositoriesGenome informationInvertebrate vectorsAnopheles gambiaeInsecticide resistancePediculus humanusVectorBaseMosquito speciesHuman pathogensAedes aegyptiSoftware infrastructureCulex quinquefasciatusIxodes scapularisAnnotation systemVector genomesData resourcesResearch communityGenomeGenomicsGambiaeSpeciesMicroarray
2006
VectorBase: a home for invertebrate vectors of human pathogens
Lawson D, Arensburger P, Atkinson P, Besansky N, Bruggner R, Butler R, Campbell K, Christophides G, Christley S, Dialynas E, Emmert D, Hammond M, Hill C, Kennedy R, Lobo N, MacCallum M, Madey G, Megy K, Redmond S, Russo S, Severson D, Stinson E, Topalis P, Zdobnov E, Birney E, Gelbart W, Kafatos F, Louis C, Collins F. VectorBase: a home for invertebrate vectors of human pathogens. Nucleic Acids Research 2006, 35: d503-d505. PMID: 17145709, PMCID: PMC1751530, DOI: 10.1093/nar/gkl960.Peer-Reviewed Original ResearchEnsembl 2006
Birney E, Andrews D, Caccamo M, Chen Y, Clarke L, Coates G, Cox T, Cunningham F, Curwen V, Cutts T, Down T, Durbin R, Fernandez-Suarez X, Flicek P, Gräf S, Hammond M, Herrero J, Howe K, Iyer V, Jekosch K, Kähäri A, Kasprzyk A, Keefe D, Kokocinski F, Kulesha E, London D, Longden I, Melsopp C, Meidl P, Overduin B, Parker A, Proctor G, Prlic A, Rae M, Rios D, Redmond S, Schuster M, Sealy I, Searle S, Severin J, Slater G, Smedley D, Smith J, Stabenau A, Stalker J, Trevanion S, Ureta-Vidal A, Vogel J, White S, Woodwark C, Hubbard T. Ensembl 2006. Nucleic Acids Research 2006, 34: d556-d561. PMID: 16381931, PMCID: PMC1347495, DOI: 10.1093/nar/gkj133.Peer-Reviewed Original ResearchConceptsGenome variation dataHuman genome variation dataNumber of genomesChordate genomesLarge genome sequencesMammalian genomesRegulatory annotationsYeast genomeRNA genesGenome sequenceCiona intestinalisGenomeVariation dataAnnotationGenesOpossumIntestinalisIntegrated sourceSequenceRhesus macaquesImport