2013
Detection of Leishmania RNA Virus in Leishmania Parasites
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA Virus in Leishmania Parasites. PLOS Neglected Tropical Diseases 2013, 7: e2006. PMID: 23326619, PMCID: PMC3542153, DOI: 10.1371/journal.pntd.0002006.Peer-Reviewed Original ResearchConceptsLeishmania RNA virusCutaneous leishmaniasisSkin lesionsPresence of LRVHyper-inflammatory immune responsePrimary skin lesionsUlcerated skin lesionsOverall exacerbationsSignificant morbidityInfected miceLesion biopsyRNA virusesSecondary lesionsImmune responseHigh riskNew World Leishmania speciesAggressive phenotypeLeishmania strainsLeishmania parasitesPatient samplesViral detectionMonoclonal antibodiesNasopharyngeal tissuesParasite strainsMetastatic phenotype
2011
Leishmania (Viannia) Infection in the Domestic Dog in Chaparral, Colombia
Santaella J, Ocampo CB, Saravia NG, Méndez F, Góngora R, Gomez MA, Munstermann LE, Quinnell RJ. Leishmania (Viannia) Infection in the Domestic Dog in Chaparral, Colombia. American Journal Of Tropical Medicine And Hygiene 2011, 84: 674-680. PMID: 21540374, PMCID: PMC3083732, DOI: 10.4269/ajtmh.2011.10-0159.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisSkin biopsy specimensHuman cutaneous leishmaniasisReservoirs of LeishmaniaEnzyme-linked immunosorbentAmerican cutaneous leishmaniasisPrevalence of infectionBiopsy specimensLeishmania infectionRisk factorsCanine infectionLeishmania guyanensisBuffy coatL. braziliensisDogsInfectionLeishmaniasisPeridomestic transmissionL. guyanensisPositive resultsBlottingMore testsDomestic dogsGuyanensisBiopsy
2010
Murine model of chronic L. (Viannia) panamensis infection: Role of IL‐13 in disease
Castilho TM, Goldsmith‐Pestana K, Lozano C, Valderrama L, Saravia NG, McMahon‐Pratt D. Murine model of chronic L. (Viannia) panamensis infection: Role of IL‐13 in disease. European Journal Of Immunology 2010, 40: 2816-2829. PMID: 20827674, PMCID: PMC3289133, DOI: 10.1002/eji.201040384.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsChronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleHumansInterferon-gammaInterleukin-13LeishmaniaLeishmaniasis, CutaneousMaleMiceMice, Inbred BALB CMice, KnockoutMiddle AgedReceptors, Interleukin-4Th1 CellsTh2 CellsTumor Necrosis Factor-alphaYoung AdultConceptsL. panamensis infectionsIL-13Panamensis infectionChronic diseasesImmunodeficient miceMurine modelMixed Th1/Th2 responseBALB/c mouse modelTh1/Th2 responsePrevalent etiologic agentHuman cutaneous leishmaniasisPresence of TNFPrevention of leishmaniasisIL-17Immunological mechanismsTh2 responsesIL-10Recurrent lesionsChronic infectionEvident lesionsMice resemblesT cellsImmune responsePersistent infectionLeishmania organisms
1993
Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis.
O'Neil C, Labrada M, Saravia N. Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis. American Journal Of Tropical Medicine And Hygiene 1993, 49: 181-8. PMID: 8357080, DOI: 10.4269/ajtmh.1993.49.181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, ProtozoanAntibody SpecificityAntigens, ProtozoanChildChild, PreschoolCross ReactionsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin AImmunoglobulin EInfantLeishmania braziliensisLeishmaniasis, CutaneousLeishmaniasis, MucocutaneousMaleRadioallergosorbent TestRetrospective StudiesConceptsAmerican tegumentary leishmaniasisIgA antibodiesEnzyme-linked immunosorbent assayTegumentary leishmaniasisRadioallergosorbent testRAST valuesHuman tegumentary leishmaniasisDuration of diseaseIgA levelsMucocutaneous diseaseBiopsy specimenBiopsy specimensCutaneous diseaseSevere formPatientsHeterologous antigensDisease evolutionIgEImmunosorbent assayElevated levelsLeishmaniasisDiseaseInhibition testingAntibodiesSeparate groups