2023
Human Borrelia miyamotoi Infection in North America
Burde J, Bloch E, Kelly J, Krause P. Human Borrelia miyamotoi Infection in North America. Pathogens 2023, 12: 553. PMID: 37111439, PMCID: PMC10145171, DOI: 10.3390/pathogens12040553.Peer-Reviewed Original ResearchClinical manifestationsLyme diseasePersonal protective strategiesCommon clinical manifestationsBlood smear examinationFebrile illnessSmear examinationLaboratory confirmationEndemic areasInfectionProtective strategiesPreventive measuresDiseaseBodied ticksManifestationsProtective clothingBorreliaTicksArthralgiaMyalgiaNauseaComplicationsHeadacheCeftriaxoneFever
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunologyFrequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents.
Johnston D, Kelly JR, Ledizet M, Lavoie N, Smith RP, Parsonnet J, Schwab J, Stratidis J, Espich S, Lee G, Maciejewski KR, Deng Y, Majam V, Zheng H, Bonkoungou SN, Stevens J, Kumar S, Krause PJ. Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents. Clinical Infectious Diseases 2022 PMID: 35325084, DOI: 10.1093/cid/ciac107.Peer-Reviewed Original ResearchBabesia microti infectionB. miyamotoiMicroti infectionB. burgdorferiB. microtiAcute undifferentiated febrile illnessCross-sectional seroprevalence studyBorrelia miyamotoiUndifferentiated febrile illnessB. miyamotoi infectionBorrelia burgdorferiLevel of seroprevalenceIxodes scapularis ticksFebrile illnessTickborne infectionMiyamotoi infectionSeroprevalence studyHuman infectionsIxodes pacificus ticksClinical casesInfectionSerum samplesAverage seroprevalenceSpecific antibodiesScapularis ticks
2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant speciesBabesiosis
Chen T, Mamoun C, Krause P. Babesiosis. 2021, 1298-1304. DOI: 10.1093/med/9780190888367.003.0200.Peer-Reviewed Original ResearchB. microtiHard-bodied ticksHuman granulocytic anaplasmosisPowassan virusEtiologic agentIntraerythrocytic protozoaLyme diseaseBorrelia miyamotoiGranulocytic anaplasmosisBabesia infectionBorrelia burgdorferiDiseaseZoonotic diseaseB. duncaniAnaplasma phagocytophilumApicomplexa phylumInfectionMicrotiB. venatorumB. divergensBabesia sppBabesiosisIxodes scapularisPrimary vectorFeverPreventing Transfusion-Transmitted Babesiosis
Bloch EM, Krause PJ, Tonnetti L. Preventing Transfusion-Transmitted Babesiosis. Pathogens 2021, 10: 1176. PMID: 34578209, PMCID: PMC8468711, DOI: 10.3390/pathogens10091176.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBlood donor testingHealthy blood donorsIntra-erythrocytic parasitesDonor surveillanceTransfusion transmissibleDonor testingHigh morbidityTransfusion recipientsSevere babesiosisBlood donorsBlood supplyBlood safetyHigh riskGlobal epidemiologyHuman babesiosisCausative agentMolecular assaysUnited StatesBabesiosisInfectionRiskMajor riskImmunopathogenesisMorbidity
2020
The emergence of human Powassan virus infection in North America
Campbell O, Krause PJ. The emergence of human Powassan virus infection in North America. Ticks And Tick-borne Diseases 2020, 11: 101540. PMID: 32993949, DOI: 10.1016/j.ttbdis.2020.101540.Peer-Reviewed Original ResearchConceptsPowassan virusPOWV infectionSymptomatic casesLong-term neurological sequelaePowassan virus infectionState health department websitesPOWV diseaseTickborne flavivirusNeurological sequelaeHealth department websitesVirus infectionDisease controlInfection prevalenceInfectionPrevalence researchUnited StatesSurveillance effortsAge distributionIncidenceOld beingSurveillance informationGreater awarenessLiterature reviewDisease incidenceMorbidity
2019
Disorders of the Immune System
Kavathas P, Krause P, Ruddle N. Disorders of the Immune System. 2019, 97-107. DOI: 10.1007/978-3-030-25553-4_6.ChaptersImmune systemImmune dysregulationHypersensitivity reactionsRegulation of autoimmunityMajor health problemHuman immune systemNumber of PIDsAllergic reactionsClinical impactAutoinflammatory diseasesForeign antigensImmune responseImmunodeficiency diseaseImmune functionHealth problemsNongenetic causesAutoimmunityHarmful responsesInborn errorsDiseaseType of disorderGenetic defectsImmunodeficiencyInfectionPredominant featureIntroduction to Immunology, Epidemiology, and Immunoepidemiology
Niccolai L, Ruddle N, Krause P. Introduction to Immunology, Epidemiology, and Immunoepidemiology. 2019, 3-17. DOI: 10.1007/978-3-030-25553-4_1.ChaptersIndividual multicellular organismsImmune responseMulticellular organismsRelevant health problemHealth-related eventsInflammatory diseasesSelect populationCombination of cellsHealth problemsEpidemiologic toolImmunoepidemiologyMicrobial infectionsEpidemiologyGenetic polymorphismsImmunologyEnvironmental factorsPopulationAutoimmunityMalignancyOrganismsInfectionDiversityDiseaseStudyInnate Immunity: Recognition and Effector Functions
Kavathas P, Krause P, Ruddle N. Innate Immunity: Recognition and Effector Functions. 2019, 39-53. DOI: 10.1007/978-3-030-25553-4_3.ChaptersDanger-associated molecular patternsPathogen-associated molecular patternsTypes of pathogensMolecular patternsInducer of inflammationSecretion of cytokinesTypes of receptorsChronic inflammationInflammatory responseEffector mechanismsEffector functionsInnate immunityInflammationComplement systemComplement proteinsMicrobial invasionReceptorsFighting infectionsInfectionCell-cell communicationSecretionCell stressNucleic acidsPathogensCellsRepeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomenHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2018
BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
Thekkiniath J, Mootien S, Lawres L, Perrin BA, Gewirtz M, Krause PJ, Williams S, Doggett J, Ledizet M, Mamoun C. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00067-18. PMID: 30093394, PMCID: PMC6156295, DOI: 10.1128/jcm.00067-18.Peer-Reviewed Original ResearchConceptsHuman babesiosisBabesia microti infectionCapture enzyme-linked immunosorbent assayAntigen capture enzyme-linked immunosorbent assayAntigen capture assayEnzyme-linked immunosorbent assayZoonotic infectious diseaseAcute infectionBlood transfusionAsymptomatic infectionMicroti infectionReal-time PCRBlood supplyAnimal reservoir hostsDonor bloodEpidemiological surveyHuman patientsImmune systemSerological assaysImmunodominant antigensInfectionInfectious diseasesIntraerythrocytic protozoan parasitePatientsImmunosorbent assayHuman Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigationHuman Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species
Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. PLOS ONE 2018, 13: e0191725. PMID: 29420552, PMCID: PMC5805228, DOI: 10.1371/journal.pone.0191725.Peer-Reviewed Original ResearchConceptsBorrelia miyamotoi infectionMiyamotoi infectionB. miyamotoiB. miyamotoi diseaseB. miyamotoi infectionB. burgdorferi infectionHealth care professionalsWhole cell lysatesSeropositive subjectsSufficient serumClinical dataBurgdorferi infectionAntibody assaysSeropositive samplesCare professionalsBorrelia antigensInfectionSerumAntibodiesBorrelia burgdorferiAntigenI. pacificus ticksMiyamotoiTick infectionFever spirochetes
2017
Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study
Kadkhoda K, Dumouchel C, Brancato J, Gretchen A, Krause PJ. Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study. CMAJ Open 2017, 5: e690-e693. PMID: 28882852, PMCID: PMC5621960, DOI: 10.9778/cmajo.20170070.Peer-Reviewed Original ResearchEnzyme-linked immunosorbent assayWestern blotLyme diseasePeptide enzyme-linked immunosorbent assayCross-sectional studyResidents of ManitobaTick-borne relapsing feverHuman seroprevalenceResidents of areasResidual seraRelapsing feverImmunosorbent assayBorrelia miyamotoiInitial reportSerumFeverInfectionDiseaseAntibodiesBlotBorreliaParticipantsSeronegativeSeropositiveHumans
2016
Hard Tick Relapsing Fever Caused by Borrelia miyamotoi in a Child
Krause P, Schwab J, Narasimhan S, Brancato J, Xu G, Rich SM. Hard Tick Relapsing Fever Caused by Borrelia miyamotoi in a Child. The Pediatric Infectious Disease Journal 2016, 35: 1352-1354. PMID: 27626914, PMCID: PMC5106309, DOI: 10.1097/inf.0000000000001330.Peer-Reviewed Original Research
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinHuman babesiosis
Chen T, Mamoun C, Krause P. Human babesiosis. 2015, 1295-1301. DOI: 10.1017/cbo9781139855952.226.Peer-Reviewed Original ResearchHuman babesiosisB. microtiB. microti infectionHard-bodied ticksClustering of casesHuman granulocytic anaplasmosisAcute illnessRenal failureBlood transfusionMicroti infectionCommon causeBabesia duncaniEndemic areasEtiologic agentHuman infectionsHuman B. microti infectionIntraerythrocytic protozoaLyme diseaseBabesia microtiBabesia speciesDiseaseGranulocytic anaplasmosisBabesia infectionIntraerythrocytic parasitesInfectionBorrelia miyamotoi infection in nature and in humans
Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology And Infection 2015, 21: 631-639. PMID: 25700888, PMCID: PMC4470780, DOI: 10.1016/j.cmi.2015.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsB. miyamotoi infectionMiyamotoi infectionClinical manifestationsB. miyamotoiLyme diseaseBorrelia miyamotoi infectionAcute febrile illnessCommon clinical manifestationsBlood smear examinationPublic health importanceHuman granulocytic anaplasmosisFever group spirochetesFebrile illnessAntibiotic therapyDisease groupEtiologic diagnosisSevere diseaseSmear examinationIxodes persulcatus ticksHealth importanceInfectionHuman casesGranulocytic anaplasmosisBorrelia miyamotoiDisease