2023
Human Borrelia miyamotoi Infection in North America
Burde J, Bloch E, Kelly J, Krause P. Human Borrelia miyamotoi Infection in North America. Pathogens 2023, 12: 553. PMID: 37111439, PMCID: PMC10145171, DOI: 10.3390/pathogens12040553.Peer-Reviewed Original ResearchClinical manifestationsLyme diseasePersonal protective strategiesCommon clinical manifestationsBlood smear examinationFebrile illnessSmear examinationLaboratory confirmationEndemic areasInfectionProtective strategiesPreventive measuresDiseaseBodied ticksManifestationsProtective clothingBorreliaTicksArthralgiaMyalgiaNauseaComplicationsHeadacheCeftriaxoneFever
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunologyBorrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient
Gandhi S, Narasimhan S, Workineh A, Mamula M, Yoon J, Krause PJ, Farhadian SF. Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient. Open Forum Infectious Diseases 2022, 9: ofac295. PMID: 35873293, PMCID: PMC9301576, DOI: 10.1093/ofid/ofac295.Peer-Reviewed Original ResearchEpidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC
Bloch EM, Day JR, Krause PJ, Kjemtrup A, O’Brien S, Tobian AAR, Goel R. Epidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 354-362. PMID: 35076004, PMCID: PMC8798708, DOI: 10.3201/eid2802.210213.Peer-Reviewed Original ResearchConceptsNational Inpatient Sample databaseInfectious Diseases journal - CDCAnalysis of hospitalizationsHospitalized patientsAdvanced ageMortality rateHospitalizationSample databaseObservation periodEpidemiologyHigher severityPatientsBabesiosisDiagnosisUnited StatesReporting dataBabesiaAdmissionIllnessIncidenceDiseaseSeverity
2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant speciesBabesiosis
Chen T, Mamoun C, Krause P. Babesiosis. 2021, 1298-1304. DOI: 10.1093/med/9780190888367.003.0200.Peer-Reviewed Original ResearchB. microtiHard-bodied ticksHuman granulocytic anaplasmosisPowassan virusEtiologic agentIntraerythrocytic protozoaLyme diseaseBorrelia miyamotoiGranulocytic anaplasmosisBabesia infectionBorrelia burgdorferiDiseaseZoonotic diseaseB. duncaniAnaplasma phagocytophilumApicomplexa phylumInfectionMicrotiB. venatorumB. divergensBabesia sppBabesiosisIxodes scapularisPrimary vectorFeverBabesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumansTick hypersensitivity and human tick‐borne diseases
Ng YQ, Gupte TP, Krause PJ. Tick hypersensitivity and human tick‐borne diseases. Parasite Immunology 2021, 43: e12819. PMID: 33428244, DOI: 10.1111/pim.12819.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsImmune responseBlood mealTick-borne diseasesGeneralized hypersensitivity reactionHuman tick-borne diseasesHost immune responseLocal hypersensitivity reactionsLaboratory animal modelsItch responseCausative pathogenTick exposureSuch vaccinesTick salivary proteinsAnimal modelsAnti-tick vaccinesMost vector-borne diseasesTick salivaHuman investigationsDiseaseTick attachmentFuture preventionBlood coagulationHypersensitivity studiesVaccine
2020
644. Borrelia miyamotoi and Borrelia burgdorferi Seroprevalence in New England
Johnston D, Kelly J, Ledizet M, Lavoie N, Krause P. 644. Borrelia miyamotoi and Borrelia burgdorferi Seroprevalence in New England. Open Forum Infectious Diseases 2020, 7: s381-s381. PMCID: PMC7777872, DOI: 10.1093/ofid/ofaa439.838.Peer-Reviewed Original ResearchSerum samplesB. burgdorferi antibodiesMethods Serum samplesNon-endemic areasResidential zip codeResidential countyBackground diseasesBurgdorferi antibodiesMultiplex LuminexStudy participantsLyme diseaseSpirochetal pathogensBorrelia miyamotoiB. miyamotoiBorrelia burgdorferiB. burgdorferiCausative agentZip codesHuman exposureDiseaseAntibodiesMiyamotoiBurgdorferiIxodes scapularisBorrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors
Brummitt SI, Kjemtrup AM, Harvey DJ, Petersen JM, Sexton C, Replogle A, Packham AE, Bloch EM, Barbour AG, Krause PJ, Green V, Smith WA. Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors. PLOS ONE 2020, 15: e0243950. PMID: 33370341, PMCID: PMC7769429, DOI: 10.1371/journal.pone.0243950.Peer-Reviewed Original ResearchConceptsLyme diseaseBlood donorsB. miyamotoiB. burgdorferiEndemic countiesWestern blotBorrelia miyamotoiB. burgdorferi antibodiesAdult blood donorsBorrelia burgdorferiIgG Western blotBlood donor seraRisk of infectionELISA test systemBurgdorferi antibodiesDonor seraC6 ELISAClinical casesEquivocal samplesHuman casesDiseaseAntibodiesI. pacificus ticksMiyamotoiBurgdorferiClinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Neurology 2020, 96: 262-273. PMID: 33257476, DOI: 10.1212/wnl.0000000000011151.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases 2020, 72: e1-e48. PMID: 33417672, DOI: 10.1093/cid/ciaa1215.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases 2020, 72: 1-8. PMID: 33483734, DOI: 10.1093/cid/ciab049.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck‐Ytter Y, Aguero‐Rosenfeld M, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner H, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care & Research 2020, 73: 1-9. PMID: 33251700, DOI: 10.1002/acr.24495.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner H, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis & Rheumatology 2020, 73: 12-20. PMID: 33251716, DOI: 10.1002/art.41562.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements105 Babesiosis
Vannier E, Krause P. 105 Babesiosis. 2020, 799-802. DOI: 10.1016/b978-0-323-55512-8.00105-8.Peer-Reviewed Original ResearchPolymerase chain reactionProphylactic antibiotic regimenLife-threatening complicationsMainstay of treatmentSolid organ transplantationBest preventive measureAntibiotic regimenFrequent symptomsHospital admissionDefinitive diagnosisSevere babesiosisBlood productsOrgan transplantationEtiologic agentBabesia microtiPreventive measuresZoonotic diseaseChain reactionB. duncaniBabesiosisDiseaseB. venatorumHemoprotozoan parasitesB. divergensAlternative option
2019
Disorders of the Immune System
Kavathas P, Krause P, Ruddle N. Disorders of the Immune System. 2019, 97-107. DOI: 10.1007/978-3-030-25553-4_6.ChaptersImmune systemImmune dysregulationHypersensitivity reactionsRegulation of autoimmunityMajor health problemHuman immune systemNumber of PIDsAllergic reactionsClinical impactAutoinflammatory diseasesForeign antigensImmune responseImmunodeficiency diseaseImmune functionHealth problemsNongenetic causesAutoimmunityHarmful responsesInborn errorsDiseaseType of disorderGenetic defectsImmunodeficiencyInfectionPredominant featureIntroduction to Immunology, Epidemiology, and Immunoepidemiology
Niccolai L, Ruddle N, Krause P. Introduction to Immunology, Epidemiology, and Immunoepidemiology. 2019, 3-17. DOI: 10.1007/978-3-030-25553-4_1.ChaptersIndividual multicellular organismsImmune responseMulticellular organismsRelevant health problemHealth-related eventsInflammatory diseasesSelect populationCombination of cellsHealth problemsEpidemiologic toolImmunoepidemiologyMicrobial infectionsEpidemiologyGenetic polymorphismsImmunologyEnvironmental factorsPopulationAutoimmunityMalignancyOrganismsInfectionDiversityDiseaseStudyHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2017
Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study
Kadkhoda K, Dumouchel C, Brancato J, Gretchen A, Krause PJ. Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study. CMAJ Open 2017, 5: e690-e693. PMID: 28882852, PMCID: PMC5621960, DOI: 10.9778/cmajo.20170070.Peer-Reviewed Original ResearchEnzyme-linked immunosorbent assayWestern blotLyme diseasePeptide enzyme-linked immunosorbent assayCross-sectional studyResidents of ManitobaTick-borne relapsing feverHuman seroprevalenceResidents of areasResidual seraRelapsing feverImmunosorbent assayBorrelia miyamotoiInitial reportSerumFeverInfectionDiseaseAntibodiesBlotBorreliaParticipantsSeronegativeSeropositiveHumans