2022
Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosis
2021
Sensitive and Feasible Specimen Collection and Testing Strategies for Diagnosing Tuberculosis in Young Children
Song R, Click ES, McCarthy KD, Heilig CM, Mchembere W, Smith JP, Fajans M, Musau SK, Okeyo E, Okumu A, Orwa J, Gethi D, Odeny L, Lee SH, Perez-Velez CM, Wright CA, Cain KP. Sensitive and Feasible Specimen Collection and Testing Strategies for Diagnosing Tuberculosis in Young Children. JAMA Pediatrics 2021, 175: e206069. PMID: 33616611, PMCID: PMC7900937, DOI: 10.1001/jamapediatrics.2020.6069.Peer-Reviewed Original ResearchConceptsGastric aspiratesNPA samplesResource-limited settingsCurrent reference standardDiagnostic yieldTuberculosis diagnosisXpert MTB/RIFCross-sectional diagnostic studyReference standardNasopharyngeal aspirate samplesSymptoms of tuberculosisMycobacteria growth indicator tube (MGIT) cultureMTB/RIFIncremental diagnostic yieldPositive test resultsYoung childrenSpecimen typesInvasive specimenCervical lymphadenopathyMedian ageMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingAspirate samples