Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions
Click ES, Song R, Smith JP, Mchembere W, Fajans M, Hariri P, Okeyo E, McCarthy KD, Gethi D, Odeny L, Musau S, Okumu A, Orwa J, Perez-Velez CM, Wright CA, Andres M, Marais BJ, Schaaf HS, Graham SM, Cruz AT, Cain KP. Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions. The Pediatric Infectious Disease Journal 2022, 41: 671-677. PMID: 35703284, PMCID: PMC9288526, DOI: 10.1097/inf.0000000000003582.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFResearch case definitionClinical case definitionMTB/RIFCase definitionIntrathoracic tuberculosisClinical characterizationMycobacterial cultureYoung childrenProspective cohort studyDifferent specimen typesDetailed clinical characterizationMultiple specimen typesSpecimen typesClinical diagnostic approachTB diseaseCohort studyMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingTuberculosis diseaseLeading causeXpert testChest radiographs