2022
Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents
Toe S, Nagy M, Albar Z, Yu J, Sattar A, Nazzinda R, Musiime V, Etajak S, Walyawula F, McComsey G, Atuyambe L, Dirajlal-Fargo S. Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents. AIDS 2022, 36: 863-870. PMID: 35131961, PMCID: PMC9081159, DOI: 10.1097/qad.0000000000003186.Peer-Reviewed Original ResearchConceptsIntima-media thicknessVascular diseaseMonocyte activationCarotid intima-media thicknessSubclinical vascular diseaseHIV-positive adolescentsMarkers of inflammationEffects of HIVCross-sectional studyMultivariable quantile regression modelsMultivariable quantile regressionAmbient air pollutionDaily ambient concentrationsDaily PM2.5 exposureExposure of PM2.5Systemic inflammationMedian ageSoluble CD163Atherosclerotic diseasePlasma markersIntestinal permeabilityCardiovascular diseaseGut integrityHIVPM2.5 exposure
2021
Lipidome association with vascular disease and inflammation in HIV+ Ugandan children
Dirajlal-Fargo S, Sattar A, Yu J, Albar Z, Chaves F, Riedl K, Kityo C, Bowman E, McComsey G, Funderburg N. Lipidome association with vascular disease and inflammation in HIV+ Ugandan children. AIDS 2021, 35: 1615-1623. PMID: 33878042, PMCID: PMC8286331, DOI: 10.1097/qad.0000000000002923.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyT cell activationCardiovascular diseaseVascular diseaseCommon carotid artery intimaSubclinical vascular diseaseSerum lipid compositionCarotid artery intimaYears of ageLipid speciesART regimenCVD riskSystemic inflammationHIV infectionMedian ageImmune activationActive infectionPlasma markersSerum lipidomeArtery intimaUgandan childrenCopies/Monocyte activationFree fatty acidsLipid classes