2021
Lipidome association with vascular disease and inflammation in HIV+ Ugandan children
Dirajlal-Fargo S, Sattar A, Yu J, Albar Z, Chaves F, Riedl K, Kityo C, Bowman E, McComsey G, Funderburg N. Lipidome association with vascular disease and inflammation in HIV+ Ugandan children. AIDS 2021, 35: 1615-1623. PMID: 33878042, PMCID: PMC8286331, DOI: 10.1097/qad.0000000000002923.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyT cell activationCardiovascular diseaseVascular diseaseCommon carotid artery intimaSubclinical vascular diseaseSerum lipid compositionCarotid artery intimaYears of ageLipid speciesART regimenCVD riskSystemic inflammationHIV infectionMedian ageImmune activationActive infectionPlasma markersSerum lipidomeArtery intimaUgandan childrenCopies/Monocyte activationFree fatty acidsLipid classes
2020
Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction.
Dirajlal-Fargo S, Yu J, Albar Z, Sattar A, Mahtab S, Jao J, Myer L, Zar H, McComsey G. Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction. AIDS 2020, 34: 1615-1623. PMID: 32769763, PMCID: PMC9390079, DOI: 10.1097/qad.0000000000002615.Peer-Reviewed Original ResearchConceptsReactive hyperemic indexGut barrier dysfunctionPoorer endothelial functionEndothelial dysfunctionMonocyte activationHIV- youthEndothelial functionBarrier dysfunctionAntiretroviral therapyLDL cholesterolLong-term clinical significanceCape Town Adolescent Antiretroviral CohortAntiretroviral therapy durationYears of ageViral suppressionHyperemic indexSystemic inflammationTherapy durationHIV- participantsMedian ageSpearman correlation coefficientViral loadSerum biomarkersSoluble CD14YLPHIV