2021
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, Wang C, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Bhattacharya R, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Kiryluk K, Neale B, Ionita-Laza I, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, Terao C, Zhao H, Ebert B, Reilly M, Ganna A, Machiela M, Genovese G, Natarajan P. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nature Medicine 2021, 27: 1012-1024. PMID: 34099924, PMCID: PMC8245201, DOI: 10.1038/s41591-021-01371-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingBiological Specimen BanksChromosome AberrationsCommunicable DiseasesDigestive System DiseasesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHematologic NeoplasmsHumansMaleMiddle AgedMosaicismPneumoniaRisk FactorsSepsisUrogenital AbnormalitiesYoung AdultConceptsMosaic chromosomal alterationsLeukocyte cell countDominant risk factorChromosomal alterationsBlood-derived DNAInfectious disease riskIncident infectionsSystem infectionGenitourinary infectionsImmune cellsRisk factorsHematological malignanciesHematological cancersCell countDisease riskInfectionInfectious diseasesClonal hematopoiesisSomatic variantsAgeRiskAlterationsWide association studyAutosomal mosaic chromosomal alterationsAssociation studies
2017
T45 Genetic Factor Common To Schizophrenia And Hiv Infection Is Associated With Risky Sexual Behavior
Wang Q, Polimanti R, Kranzler H, Farrer L, Zhao H, Gelernter J. T45 Genetic Factor Common To Schizophrenia And Hiv Infection Is Associated With Risky Sexual Behavior. European Neuropsychopharmacology 2017, 27: s460-s461. DOI: 10.1016/j.euroneuro.2016.09.533.Peer-Reviewed Original ResearchRisky sexual behaviorBody mass indexHIV infectionPolygenic risk scoresRisk scoreSexual behaviorHuman immunodeficiency virus (HIV) infectionSame effect directionImmunodeficiency virus infectionSZ-polygenic risk scoreGenetic risk factorsGenetic risk scoreSemi-Structured AssessmentMass indexRisk factorsEpidemiologic correlationsVirus infectionObservational studySynaptic transmissionHIVBipolar disorderNerve impulse transmissionSerious disorderDrug dependenceInfection